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Prenatal Restraint Stress Generates Two Distinct Behavioral and Neurochemical Profiles in Male and Female Rats
Prenatal Restraint Stress (PRS) in rats is a validated model of early stress resulting in permanent behavioral and neurobiological outcomes. Although sexual dimorphism in the effects of PRS has been hypothesized for more than 30 years, few studies in this long period have directly addressed the issu...
Autores principales: | , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366064/ https://www.ncbi.nlm.nih.gov/pubmed/18478112 http://dx.doi.org/10.1371/journal.pone.0002170 |
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author | Zuena, Anna Rita Mairesse, Jerome Casolini, Paola Cinque, Carlo Alemà, Giovanni Sebastiano Morley-Fletcher, Sara Chiodi, Valentina Spagnoli, Luigi Giusto Gradini, Roberto Catalani, Assia Nicoletti, Ferdinando Maccari, Stefania |
author_facet | Zuena, Anna Rita Mairesse, Jerome Casolini, Paola Cinque, Carlo Alemà, Giovanni Sebastiano Morley-Fletcher, Sara Chiodi, Valentina Spagnoli, Luigi Giusto Gradini, Roberto Catalani, Assia Nicoletti, Ferdinando Maccari, Stefania |
author_sort | Zuena, Anna Rita |
collection | PubMed |
description | Prenatal Restraint Stress (PRS) in rats is a validated model of early stress resulting in permanent behavioral and neurobiological outcomes. Although sexual dimorphism in the effects of PRS has been hypothesized for more than 30 years, few studies in this long period have directly addressed the issue. Our group has uncovered a pronounced gender difference in the effects of PRS (stress delivered to the mothers 3 times per day during the last 10 days of pregnancy) on anxiety, spatial learning, and a series of neurobiological parameters classically associated with hippocampus-dependent behaviors. Adult male rats subjected to PRS (“PRS rats”) showed increased anxiety-like behavior in the elevated plus maze (EPM), a reduction in the survival of newborn cells in the dentate gyrus, a reduction in the activity of mGlu1/5 metabotropic glutamate receptors in the ventral hippocampus, and an increase in the levels of brain-derived neurotrophic factor (BDNF) and pro-BDNF in the hippocampus. In contrast, female PRS rats displayed reduced anxiety in the EPM, improved learning in the Morris water maze, an increase in the activity of mGlu1/5 receptors in the ventral and dorsal hippocampus, and no changes in hippocampal neurogenesis or BDNF levels. The direction of the changes in neurogenesis, BDNF levels and mGlu receptor function in PRS animals was not consistent with the behavioral changes, suggesting that PRS perturbs the interdependency of these particular parameters and their relation to hippocampus-dependent behavior. Our data suggest that the epigenetic changes in hippocampal neuroplasticity induced by early environmental challenges are critically sex-dependent and that the behavioral outcome may diverge in males and females. |
format | Text |
id | pubmed-2366064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-23660642008-05-14 Prenatal Restraint Stress Generates Two Distinct Behavioral and Neurochemical Profiles in Male and Female Rats Zuena, Anna Rita Mairesse, Jerome Casolini, Paola Cinque, Carlo Alemà, Giovanni Sebastiano Morley-Fletcher, Sara Chiodi, Valentina Spagnoli, Luigi Giusto Gradini, Roberto Catalani, Assia Nicoletti, Ferdinando Maccari, Stefania PLoS One Research Article Prenatal Restraint Stress (PRS) in rats is a validated model of early stress resulting in permanent behavioral and neurobiological outcomes. Although sexual dimorphism in the effects of PRS has been hypothesized for more than 30 years, few studies in this long period have directly addressed the issue. Our group has uncovered a pronounced gender difference in the effects of PRS (stress delivered to the mothers 3 times per day during the last 10 days of pregnancy) on anxiety, spatial learning, and a series of neurobiological parameters classically associated with hippocampus-dependent behaviors. Adult male rats subjected to PRS (“PRS rats”) showed increased anxiety-like behavior in the elevated plus maze (EPM), a reduction in the survival of newborn cells in the dentate gyrus, a reduction in the activity of mGlu1/5 metabotropic glutamate receptors in the ventral hippocampus, and an increase in the levels of brain-derived neurotrophic factor (BDNF) and pro-BDNF in the hippocampus. In contrast, female PRS rats displayed reduced anxiety in the EPM, improved learning in the Morris water maze, an increase in the activity of mGlu1/5 receptors in the ventral and dorsal hippocampus, and no changes in hippocampal neurogenesis or BDNF levels. The direction of the changes in neurogenesis, BDNF levels and mGlu receptor function in PRS animals was not consistent with the behavioral changes, suggesting that PRS perturbs the interdependency of these particular parameters and their relation to hippocampus-dependent behavior. Our data suggest that the epigenetic changes in hippocampal neuroplasticity induced by early environmental challenges are critically sex-dependent and that the behavioral outcome may diverge in males and females. Public Library of Science 2008-05-14 /pmc/articles/PMC2366064/ /pubmed/18478112 http://dx.doi.org/10.1371/journal.pone.0002170 Text en Zuena et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Zuena, Anna Rita Mairesse, Jerome Casolini, Paola Cinque, Carlo Alemà, Giovanni Sebastiano Morley-Fletcher, Sara Chiodi, Valentina Spagnoli, Luigi Giusto Gradini, Roberto Catalani, Assia Nicoletti, Ferdinando Maccari, Stefania Prenatal Restraint Stress Generates Two Distinct Behavioral and Neurochemical Profiles in Male and Female Rats |
title | Prenatal Restraint Stress Generates Two Distinct Behavioral and Neurochemical Profiles in Male and Female Rats |
title_full | Prenatal Restraint Stress Generates Two Distinct Behavioral and Neurochemical Profiles in Male and Female Rats |
title_fullStr | Prenatal Restraint Stress Generates Two Distinct Behavioral and Neurochemical Profiles in Male and Female Rats |
title_full_unstemmed | Prenatal Restraint Stress Generates Two Distinct Behavioral and Neurochemical Profiles in Male and Female Rats |
title_short | Prenatal Restraint Stress Generates Two Distinct Behavioral and Neurochemical Profiles in Male and Female Rats |
title_sort | prenatal restraint stress generates two distinct behavioral and neurochemical profiles in male and female rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366064/ https://www.ncbi.nlm.nih.gov/pubmed/18478112 http://dx.doi.org/10.1371/journal.pone.0002170 |
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