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Biological Monitoring of Hexavalent Chromium and Serum Levels of the Senescence Biomarker Apolipoprotein J/Clusterin in Welders

Welding fumes contain metals and other toxic substances known or strongly suspected to be related with oxidative stress and premature cellular senescence. Apolipoprotein J/Clusterin (ApoJ/CLU) is a glycoprotein that is differentially regulated in various physiological and disease states including ag...

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Autores principales: Alexopoulos, Evangelos C., Cominos, Xenophon, Trougakos, Ioannis P., Lourda, Magda, Gonos, Efstathios S., Makropoulos, Vassilios
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366075/
https://www.ncbi.nlm.nih.gov/pubmed/18464919
http://dx.doi.org/10.1155/2008/420578
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author Alexopoulos, Evangelos C.
Cominos, Xenophon
Trougakos, Ioannis P.
Lourda, Magda
Gonos, Efstathios S.
Makropoulos, Vassilios
author_facet Alexopoulos, Evangelos C.
Cominos, Xenophon
Trougakos, Ioannis P.
Lourda, Magda
Gonos, Efstathios S.
Makropoulos, Vassilios
author_sort Alexopoulos, Evangelos C.
collection PubMed
description Welding fumes contain metals and other toxic substances known or strongly suspected to be related with oxidative stress and premature cellular senescence. Apolipoprotein J/Clusterin (ApoJ/CLU) is a glycoprotein that is differentially regulated in various physiological and disease states including ageing and age-related diseases. In vitro data showed that exposure of human diploid fibroblasts to hexavalent chromium (Cr(VI)) resulted in premature senescence and significant upregulation of the ApoJ/CLU protein. In this study we analyzed blood and urine samples from shipyard industry welders being exposed to different levels of Cr(VI) over a period of five months in order to assay in vivo the relation of ApoJ/CLU serum levels with Cr(VI). Our findings confirmed the previously reported in vitro data since reduction of Cr levels, after a worksite intervention, associated with lower levels of ApoJ/CLU serum levels. We concluded that the human ApoJ/CLU gene is responsive to the acute in vivo oxidative stress induced by heavy metals such as hexavalent chromium.
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spelling pubmed-23660752008-05-08 Biological Monitoring of Hexavalent Chromium and Serum Levels of the Senescence Biomarker Apolipoprotein J/Clusterin in Welders Alexopoulos, Evangelos C. Cominos, Xenophon Trougakos, Ioannis P. Lourda, Magda Gonos, Efstathios S. Makropoulos, Vassilios Bioinorg Chem Appl Research Article Welding fumes contain metals and other toxic substances known or strongly suspected to be related with oxidative stress and premature cellular senescence. Apolipoprotein J/Clusterin (ApoJ/CLU) is a glycoprotein that is differentially regulated in various physiological and disease states including ageing and age-related diseases. In vitro data showed that exposure of human diploid fibroblasts to hexavalent chromium (Cr(VI)) resulted in premature senescence and significant upregulation of the ApoJ/CLU protein. In this study we analyzed blood and urine samples from shipyard industry welders being exposed to different levels of Cr(VI) over a period of five months in order to assay in vivo the relation of ApoJ/CLU serum levels with Cr(VI). Our findings confirmed the previously reported in vitro data since reduction of Cr levels, after a worksite intervention, associated with lower levels of ApoJ/CLU serum levels. We concluded that the human ApoJ/CLU gene is responsive to the acute in vivo oxidative stress induced by heavy metals such as hexavalent chromium. Hindawi Publishing Corporation 2008 2008-04-22 /pmc/articles/PMC2366075/ /pubmed/18464919 http://dx.doi.org/10.1155/2008/420578 Text en Copyright © 2008 Evangelos C. Alexopoulos et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Alexopoulos, Evangelos C.
Cominos, Xenophon
Trougakos, Ioannis P.
Lourda, Magda
Gonos, Efstathios S.
Makropoulos, Vassilios
Biological Monitoring of Hexavalent Chromium and Serum Levels of the Senescence Biomarker Apolipoprotein J/Clusterin in Welders
title Biological Monitoring of Hexavalent Chromium and Serum Levels of the Senescence Biomarker Apolipoprotein J/Clusterin in Welders
title_full Biological Monitoring of Hexavalent Chromium and Serum Levels of the Senescence Biomarker Apolipoprotein J/Clusterin in Welders
title_fullStr Biological Monitoring of Hexavalent Chromium and Serum Levels of the Senescence Biomarker Apolipoprotein J/Clusterin in Welders
title_full_unstemmed Biological Monitoring of Hexavalent Chromium and Serum Levels of the Senescence Biomarker Apolipoprotein J/Clusterin in Welders
title_short Biological Monitoring of Hexavalent Chromium and Serum Levels of the Senescence Biomarker Apolipoprotein J/Clusterin in Welders
title_sort biological monitoring of hexavalent chromium and serum levels of the senescence biomarker apolipoprotein j/clusterin in welders
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366075/
https://www.ncbi.nlm.nih.gov/pubmed/18464919
http://dx.doi.org/10.1155/2008/420578
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