Hormone Anchored Metal Complexes. 1. Synthesis, Structure, Spectroscopy and In Vitro Antitumor Activity of Testosterone Acetate Thiosemicarbazone and its Metal Complexes

Testosterone acetate thiosemicarbazone (TATSC, 17-β-hydroxyandrost-4-one acetate thiosemicarbazone) was synthesized and characterized by single crystal X-ray structure determination. The copper and platinum complexes of this steroid derivative were synthesized and characterized by spectroscopy and e...

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Autores principales: Murugkar, Anupa, Unnikrishnan, Bindu, Padhye, Subhash, Bhonde, Ramesh, Teat, Simon, Triantafillou, Evangelia, Sinn, Ekkehard
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1999
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366831/
https://www.ncbi.nlm.nih.gov/pubmed/18472909
http://dx.doi.org/10.1155/MBD.1999.177
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author Murugkar, Anupa
Unnikrishnan, Bindu
Padhye, Subhash
Bhonde, Ramesh
Teat, Simon
Triantafillou, Evangelia
Sinn, Ekkehard
author_facet Murugkar, Anupa
Unnikrishnan, Bindu
Padhye, Subhash
Bhonde, Ramesh
Teat, Simon
Triantafillou, Evangelia
Sinn, Ekkehard
author_sort Murugkar, Anupa
collection PubMed
description Testosterone acetate thiosemicarbazone (TATSC, 17-β-hydroxyandrost-4-one acetate thiosemicarbazone) was synthesized and characterized by single crystal X-ray structure determination. The copper and platinum complexes of this steroid derivative were synthesized and characterized by spectroscopy and electrochemiatry. The in vitro activity of these compounds against human breast cancer cell line MCF-7 was tested. The highest activity was found for the [Pt(TATSC)Cl(1)] followed by [Cu(TATSC)Cl(2)] and the ligand in compariosn with cisplatin.
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spelling pubmed-23668312008-05-12 Hormone Anchored Metal Complexes. 1. Synthesis, Structure, Spectroscopy and In Vitro Antitumor Activity of Testosterone Acetate Thiosemicarbazone and its Metal Complexes Murugkar, Anupa Unnikrishnan, Bindu Padhye, Subhash Bhonde, Ramesh Teat, Simon Triantafillou, Evangelia Sinn, Ekkehard Met Based Drugs Research Article Testosterone acetate thiosemicarbazone (TATSC, 17-β-hydroxyandrost-4-one acetate thiosemicarbazone) was synthesized and characterized by single crystal X-ray structure determination. The copper and platinum complexes of this steroid derivative were synthesized and characterized by spectroscopy and electrochemiatry. The in vitro activity of these compounds against human breast cancer cell line MCF-7 was tested. The highest activity was found for the [Pt(TATSC)Cl(1)] followed by [Cu(TATSC)Cl(2)] and the ligand in compariosn with cisplatin. Hindawi Publishing Corporation 1999 /pmc/articles/PMC2366831/ /pubmed/18472909 http://dx.doi.org/10.1155/MBD.1999.177 Text en Copyright © 1999 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Murugkar, Anupa
Unnikrishnan, Bindu
Padhye, Subhash
Bhonde, Ramesh
Teat, Simon
Triantafillou, Evangelia
Sinn, Ekkehard
Hormone Anchored Metal Complexes. 1. Synthesis, Structure, Spectroscopy and In Vitro Antitumor Activity of Testosterone Acetate Thiosemicarbazone and its Metal Complexes
title Hormone Anchored Metal Complexes. 1. Synthesis, Structure, Spectroscopy and In Vitro Antitumor Activity of Testosterone Acetate Thiosemicarbazone and its Metal Complexes
title_full Hormone Anchored Metal Complexes. 1. Synthesis, Structure, Spectroscopy and In Vitro Antitumor Activity of Testosterone Acetate Thiosemicarbazone and its Metal Complexes
title_fullStr Hormone Anchored Metal Complexes. 1. Synthesis, Structure, Spectroscopy and In Vitro Antitumor Activity of Testosterone Acetate Thiosemicarbazone and its Metal Complexes
title_full_unstemmed Hormone Anchored Metal Complexes. 1. Synthesis, Structure, Spectroscopy and In Vitro Antitumor Activity of Testosterone Acetate Thiosemicarbazone and its Metal Complexes
title_short Hormone Anchored Metal Complexes. 1. Synthesis, Structure, Spectroscopy and In Vitro Antitumor Activity of Testosterone Acetate Thiosemicarbazone and its Metal Complexes
title_sort hormone anchored metal complexes. 1. synthesis, structure, spectroscopy and in vitro antitumor activity of testosterone acetate thiosemicarbazone and its metal complexes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366831/
https://www.ncbi.nlm.nih.gov/pubmed/18472909
http://dx.doi.org/10.1155/MBD.1999.177
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