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Interferon-γ Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes

Monocyte chemotactic protein (MCP-1) is a specific monocyte chemoattractant and activating factor produced by both immune cells (mononuclear phagocytes and lymphocytes) and non-immune cells (parenchymal and stromal cells). In order to define the conditions under which human monocytes express MCP-1,...

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Detalles Bibliográficos
Autores principales: Liebler, J. M., Kunkel, S. L., Allen, R. M., Burdick, M. D., Strieter, R. M.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1994
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367013/
https://www.ncbi.nlm.nih.gov/pubmed/18472920
http://dx.doi.org/10.1155/S0962935194000050
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author Liebler, J. M.
Kunkel, S. L.
Allen, R. M.
Burdick, M. D.
Strieter, R. M.
author_facet Liebler, J. M.
Kunkel, S. L.
Allen, R. M.
Burdick, M. D.
Strieter, R. M.
author_sort Liebler, J. M.
collection PubMed
description Monocyte chemotactic protein (MCP-1) is a specific monocyte chemoattractant and activating factor produced by both immune cells (mononuclear phagocytes and lymphocytes) and non-immune cells (parenchymal and stromal cells). In order to define the conditions under which human monocytes express MCP-1, monocytes were exposed to IFN-γ, IL- lβ, TNF-α, IL-4 or PHA under serum free conditions. There was no significant MCP-1 production by monocytes following exposure to IL-lβ, TNF-α or IL-4. In contrast, stimulation with IFN-γ resulted in a dose dependent increase in MCP-1 protein and mRNA expression. Simultaneous stimulation with IFN-γ and IL-1β or TNF-α resulted in no further increase in MCP-1 production. It is concluded that IFN-γ, primarily a product of T(H)1 T lymphocytes, stimulates the expression of MCP-1 by monocytes.
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spelling pubmed-23670132008-05-12 Interferon-γ Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes Liebler, J. M. Kunkel, S. L. Allen, R. M. Burdick, M. D. Strieter, R. M. Mediators Inflamm Research Article Monocyte chemotactic protein (MCP-1) is a specific monocyte chemoattractant and activating factor produced by both immune cells (mononuclear phagocytes and lymphocytes) and non-immune cells (parenchymal and stromal cells). In order to define the conditions under which human monocytes express MCP-1, monocytes were exposed to IFN-γ, IL- lβ, TNF-α, IL-4 or PHA under serum free conditions. There was no significant MCP-1 production by monocytes following exposure to IL-lβ, TNF-α or IL-4. In contrast, stimulation with IFN-γ resulted in a dose dependent increase in MCP-1 protein and mRNA expression. Simultaneous stimulation with IFN-γ and IL-1β or TNF-α resulted in no further increase in MCP-1 production. It is concluded that IFN-γ, primarily a product of T(H)1 T lymphocytes, stimulates the expression of MCP-1 by monocytes. Hindawi Publishing Corporation 1994 /pmc/articles/PMC2367013/ /pubmed/18472920 http://dx.doi.org/10.1155/S0962935194000050 Text en Copyright © 1994 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liebler, J. M.
Kunkel, S. L.
Allen, R. M.
Burdick, M. D.
Strieter, R. M.
Interferon-γ Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes
title Interferon-γ Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes
title_full Interferon-γ Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes
title_fullStr Interferon-γ Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes
title_full_unstemmed Interferon-γ Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes
title_short Interferon-γ Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes
title_sort interferon-γ stimulates monocyte chemotactic protein-1 expression by monocytes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367013/
https://www.ncbi.nlm.nih.gov/pubmed/18472920
http://dx.doi.org/10.1155/S0962935194000050
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