A novel Mutein of TNFα Containing the Arg-Gly-Asp Sequence Shows Reduced Toxicity in Intestine

The effects of human tumour necrosis factor-α (TNFα), or its mutein (F4168) having the cell adhesive Arg-Gly-Asp sequence at the N-terminus, on intestinal injury, were examined. Histopathological examination revealed that an intravenous injection of TNFα resulted in marked haemorrhage or oedema in t...

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Detalles Bibliográficos
Autores principales: Shikama, H., Miyata, K., Sakae, N., Kuroda, K., Nishimura, K., Yotsuya, S., Kato, M.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367030/
https://www.ncbi.nlm.nih.gov/pubmed/18472928
http://dx.doi.org/10.1155/S096293519400013X

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367030/
https://www.ncbi.nlm.nih.gov/pubmed/18472928
http://dx.doi.org/10.1155/S096293519400013X

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