The Effect of Steroid Treatment on Lipocortin Immunoreactivity of Rat Brain

Lipocortin-1, lipocortin-2 and lipocortin-5 were immunohistochemically assessed in rats. Apart from animals receiving no treatment, other animals received pretreatment with methylprednisolone, or the 21-aminosteroid U-74389F. Whereas Hpocortin immunoreactivity was absent in the greater part of the b...

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Autores principales: Go, K. G., Ter Haar, J. G., de Ley, L., Zuiderveen, F., Parente, L., Solito, E., Molenaar, W. M.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367041/
https://www.ncbi.nlm.nih.gov/pubmed/18472938
http://dx.doi.org/10.1155/S0962935194000232
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author Go, K. G.
Ter Haar, J. G.
de Ley, L.
Zuiderveen, F.
Parente, L.
Solito, E.
Molenaar, W. M.
author_facet Go, K. G.
Ter Haar, J. G.
de Ley, L.
Zuiderveen, F.
Parente, L.
Solito, E.
Molenaar, W. M.
author_sort Go, K. G.
collection PubMed
description Lipocortin-1, lipocortin-2 and lipocortin-5 were immunohistochemically assessed in rats. Apart from animals receiving no treatment, other animals received pretreatment with methylprednisolone, or the 21-aminosteroid U-74389F. Whereas Hpocortin immunoreactivity was absent in the greater part of the brain in animals not pretreated with steroid (except in sporadic microglial cells and choroid plexus), there was obvious immunostaining of parenchymatous elements in steroid pretreated animals. In the steroid pretreated animals lipocortin immunoreactivity of the brain tissue may indicate local formation of lipocortin under the influence of steroids that had entered the tissue. The cellular elements which showed immunostaining included meningeal cells, neurones, ependyma, oligodendroglia and capillary endotheHum.
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spelling pubmed-23670412008-05-12 The Effect of Steroid Treatment on Lipocortin Immunoreactivity of Rat Brain Go, K. G. Ter Haar, J. G. de Ley, L. Zuiderveen, F. Parente, L. Solito, E. Molenaar, W. M. Mediators Inflamm Research Article Lipocortin-1, lipocortin-2 and lipocortin-5 were immunohistochemically assessed in rats. Apart from animals receiving no treatment, other animals received pretreatment with methylprednisolone, or the 21-aminosteroid U-74389F. Whereas Hpocortin immunoreactivity was absent in the greater part of the brain in animals not pretreated with steroid (except in sporadic microglial cells and choroid plexus), there was obvious immunostaining of parenchymatous elements in steroid pretreated animals. In the steroid pretreated animals lipocortin immunoreactivity of the brain tissue may indicate local formation of lipocortin under the influence of steroids that had entered the tissue. The cellular elements which showed immunostaining included meningeal cells, neurones, ependyma, oligodendroglia and capillary endotheHum. Hindawi Publishing Corporation 1994 /pmc/articles/PMC2367041/ /pubmed/18472938 http://dx.doi.org/10.1155/S0962935194000232 Text en Copyright © 1994 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Go, K. G.
Ter Haar, J. G.
de Ley, L.
Zuiderveen, F.
Parente, L.
Solito, E.
Molenaar, W. M.
The Effect of Steroid Treatment on Lipocortin Immunoreactivity of Rat Brain
title The Effect of Steroid Treatment on Lipocortin Immunoreactivity of Rat Brain
title_full The Effect of Steroid Treatment on Lipocortin Immunoreactivity of Rat Brain
title_fullStr The Effect of Steroid Treatment on Lipocortin Immunoreactivity of Rat Brain
title_full_unstemmed The Effect of Steroid Treatment on Lipocortin Immunoreactivity of Rat Brain
title_short The Effect of Steroid Treatment on Lipocortin Immunoreactivity of Rat Brain
title_sort effect of steroid treatment on lipocortin immunoreactivity of rat brain
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367041/
https://www.ncbi.nlm.nih.gov/pubmed/18472938
http://dx.doi.org/10.1155/S0962935194000232
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