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Hyaluronic Acid Inhibits Polycation Induced Cellular Responses
Positively charged macromolecules cause a variety of pathological events through their electrostatic interaction with anionic sites present on the membrane of target cells. In the present study we have investigated the effect of hyaluronic acid, a negatively charged molecule, on rat paw oedema induc...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
1994
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367052/ https://www.ncbi.nlm.nih.gov/pubmed/18472954 http://dx.doi.org/10.1155/S0962935194000396 |
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author | lalenti, A. lanaro, A. Brignola, G. Marotta, P. Di Rosa, M. |
author_facet | lalenti, A. lanaro, A. Brignola, G. Marotta, P. Di Rosa, M. |
author_sort | lalenti, A. |
collection | PubMed |
description | Positively charged macromolecules cause a variety of pathological events through their electrostatic interaction with anionic sites present on the membrane of target cells. In the present study we have investigated the effect of hyaluronic acid, a negatively charged molecule, on rat paw oedema induced by poly-L-lysine as well as on histamine release from rat mast cells and nitric oxide formation from rabbit aorta, both induced by this polycation. The results indicate that hyaluronic acid is able to suppress these poly-L-lysine induced effects with a mechanism which possibly depends on its negative charges which may balance the effects of positively charged polycations. |
format | Text |
id | pubmed-2367052 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1994 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-23670522008-05-12 Hyaluronic Acid Inhibits Polycation Induced Cellular Responses lalenti, A. lanaro, A. Brignola, G. Marotta, P. Di Rosa, M. Mediators Inflamm Research Article Positively charged macromolecules cause a variety of pathological events through their electrostatic interaction with anionic sites present on the membrane of target cells. In the present study we have investigated the effect of hyaluronic acid, a negatively charged molecule, on rat paw oedema induced by poly-L-lysine as well as on histamine release from rat mast cells and nitric oxide formation from rabbit aorta, both induced by this polycation. The results indicate that hyaluronic acid is able to suppress these poly-L-lysine induced effects with a mechanism which possibly depends on its negative charges which may balance the effects of positively charged polycations. Hindawi Publishing Corporation 1994 /pmc/articles/PMC2367052/ /pubmed/18472954 http://dx.doi.org/10.1155/S0962935194000396 Text en Copyright © 1994 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article lalenti, A. lanaro, A. Brignola, G. Marotta, P. Di Rosa, M. Hyaluronic Acid Inhibits Polycation Induced Cellular Responses |
title | Hyaluronic Acid Inhibits Polycation Induced Cellular Responses |
title_full | Hyaluronic Acid Inhibits Polycation Induced Cellular Responses |
title_fullStr | Hyaluronic Acid Inhibits Polycation Induced Cellular Responses |
title_full_unstemmed | Hyaluronic Acid Inhibits Polycation Induced Cellular Responses |
title_short | Hyaluronic Acid Inhibits Polycation Induced Cellular Responses |
title_sort | hyaluronic acid inhibits polycation induced cellular responses |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367052/ https://www.ncbi.nlm.nih.gov/pubmed/18472954 http://dx.doi.org/10.1155/S0962935194000396 |
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