Differential Effects of Domoic Acid and E. coli Lipopolysaccharide on Tumor Necrosis Factor-α, Transforming Growth Factor-β1 and Matrix Metalloproteinase-9 Release by Rat Neonatal Microglia: Evaluation of the Direct Activation Hypothesis

The excitatory amino acid domoic acid is the causative agent of amnesic shellfish poisoning in humans. The in vitro effects of domoic acid on rat neonatal brain microglia were compared with E. coli lipopolysaccharide (LPS), a known activator of microglia mediator release over a 4 to 24 hour observat...

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Detalles Bibliográficos
Autores principales: Mayer, Alejandro M. S., Guzman, Marcio, Peksa, Renee, Hall, Mary, Fay, Michael J., Jacobson, Peer B., Romanic, Anne M., Gunasekera, Sarath P.
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2007
Materias:
Full Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367328/
https://www.ncbi.nlm.nih.gov/pubmed/18458762

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