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Excessive Islet NO Generation in Type 2 Diabetic GK Rats Coincides with Abnormal Hormone Secretion and Is Counteracted by GLP-1

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BACKGROUND: A distinctive feature of type 2 diabetes is inability of insulin-secreting β-cells to properly respond to elevated glucose eventually leading to β-cell failure. We have hypothesized that an abnormally increased NO production in the pancreatic islets might be an important factor in the pa...

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Detalles Bibliográficos
Autores principales:	Salehi, Albert, Meidute Abaraviciene, Sandra, Jimenez-Feltstrom, Javier, Östenson, Claes-Göran, Efendic, Suad, Lundquist, Ingmar
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367446/ https://www.ncbi.nlm.nih.gov/pubmed/18478125 http://dx.doi.org/10.1371/journal.pone.0002165

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