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A genome-wide linkage study of GAW15 gene expression data
BACKGROUND: Recently, gene expression levels have been shown to demonstrate familial aggregation, suggesting a direct role of heritable DNA variation. We studied the gene expression levels in lymphoblastoid cells of the Centre d'Etude du Polymorphisme Humain Utah families made available to Gene...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367464/ https://www.ncbi.nlm.nih.gov/pubmed/18466590 |
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author | Kan, Donghui Cooper, Richard Zhu, Xiaofeng |
author_facet | Kan, Donghui Cooper, Richard Zhu, Xiaofeng |
author_sort | Kan, Donghui |
collection | PubMed |
description | BACKGROUND: Recently, gene expression levels have been shown to demonstrate familial aggregation, suggesting a direct role of heritable DNA variation. We studied the gene expression levels in lymphoblastoid cells of the Centre d'Etude du Polymorphisme Humain Utah families made available to Genetic Analysis Workshop 15 (GAW15), using genome-wide linkage analyses. METHODS: Heritability was estimated for the expression levels of each individual phenotype. Genome wide linkage analysis was then performed using the 2819 SNPs for the expression levels of all the genes. RESULTS: Heritability exceeded 0.21 for 50% of the expressed phenotypes. Genome-wide linkage analysis demonstrated that 19 of them reached significance after correcting for multiple comparisons, only 4 of which were reported previously. We did not identify any hot spots of transcriptional regulation when assuming LOD score > 5.3 for significant linkage evidence. CONCLUSION: Our analysis suggests that inconsistent results in comparison to the previous report may be due to the different approaches, phenotype transformation, and different pedigree data used in the analyses. |
format | Text |
id | pubmed-2367464 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-23674642008-05-06 A genome-wide linkage study of GAW15 gene expression data Kan, Donghui Cooper, Richard Zhu, Xiaofeng BMC Proc Proceedings BACKGROUND: Recently, gene expression levels have been shown to demonstrate familial aggregation, suggesting a direct role of heritable DNA variation. We studied the gene expression levels in lymphoblastoid cells of the Centre d'Etude du Polymorphisme Humain Utah families made available to Genetic Analysis Workshop 15 (GAW15), using genome-wide linkage analyses. METHODS: Heritability was estimated for the expression levels of each individual phenotype. Genome wide linkage analysis was then performed using the 2819 SNPs for the expression levels of all the genes. RESULTS: Heritability exceeded 0.21 for 50% of the expressed phenotypes. Genome-wide linkage analysis demonstrated that 19 of them reached significance after correcting for multiple comparisons, only 4 of which were reported previously. We did not identify any hot spots of transcriptional regulation when assuming LOD score > 5.3 for significant linkage evidence. CONCLUSION: Our analysis suggests that inconsistent results in comparison to the previous report may be due to the different approaches, phenotype transformation, and different pedigree data used in the analyses. BioMed Central 2007-12-18 /pmc/articles/PMC2367464/ /pubmed/18466590 Text en Copyright © 2007 Kan et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Proceedings Kan, Donghui Cooper, Richard Zhu, Xiaofeng A genome-wide linkage study of GAW15 gene expression data |
title | A genome-wide linkage study of GAW15 gene expression data |
title_full | A genome-wide linkage study of GAW15 gene expression data |
title_fullStr | A genome-wide linkage study of GAW15 gene expression data |
title_full_unstemmed | A genome-wide linkage study of GAW15 gene expression data |
title_short | A genome-wide linkage study of GAW15 gene expression data |
title_sort | genome-wide linkage study of gaw15 gene expression data |
topic | Proceedings |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367464/ https://www.ncbi.nlm.nih.gov/pubmed/18466590 |
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