Using the maternal-fetal genotype incompatibility test to assess non-inherited maternal HLA-DRB1 antigen coding alleles as rheumatoid arthritis risk factors

Non-inherited maternal antigens encoded by specific HLA-DRB1 alleles (NIMA) have been implicated as a rheumatoid arthritis (RA) risk factor. Using genotype data from North American Rheumatoid Arthritis Consortium study participants and the maternal-fetal genotype incompatibility (MFG) test, we find...

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Autores principales: Hsieh, Hsin-Ju, Palmer, Christina GS, Harney, Sinead, Chen, Hsiu-Wen, Bauman, Lara, Brown, Matthew A, Sinsheimer, Janet S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367472/
https://www.ncbi.nlm.nih.gov/pubmed/18466466
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author Hsieh, Hsin-Ju
Palmer, Christina GS
Harney, Sinead
Chen, Hsiu-Wen
Bauman, Lara
Brown, Matthew A
Sinsheimer, Janet S
author_facet Hsieh, Hsin-Ju
Palmer, Christina GS
Harney, Sinead
Chen, Hsiu-Wen
Bauman, Lara
Brown, Matthew A
Sinsheimer, Janet S
author_sort Hsieh, Hsin-Ju
collection PubMed
description Non-inherited maternal antigens encoded by specific HLA-DRB1 alleles (NIMA) have been implicated as a rheumatoid arthritis (RA) risk factor. Using genotype data from North American Rheumatoid Arthritis Consortium study participants and the maternal-fetal genotype incompatibility (MFG) test, we find evidence for offspring allelic effects but no evidence for NIMA as a RA risk factor. We discuss possible reasons why our result conflicts with several previous studies (including one of our own) that used RA patients from northern Europe.
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spelling pubmed-23674722008-05-06 Using the maternal-fetal genotype incompatibility test to assess non-inherited maternal HLA-DRB1 antigen coding alleles as rheumatoid arthritis risk factors Hsieh, Hsin-Ju Palmer, Christina GS Harney, Sinead Chen, Hsiu-Wen Bauman, Lara Brown, Matthew A Sinsheimer, Janet S BMC Proc Proceedings Non-inherited maternal antigens encoded by specific HLA-DRB1 alleles (NIMA) have been implicated as a rheumatoid arthritis (RA) risk factor. Using genotype data from North American Rheumatoid Arthritis Consortium study participants and the maternal-fetal genotype incompatibility (MFG) test, we find evidence for offspring allelic effects but no evidence for NIMA as a RA risk factor. We discuss possible reasons why our result conflicts with several previous studies (including one of our own) that used RA patients from northern Europe. BioMed Central 2007-12-18 /pmc/articles/PMC2367472/ /pubmed/18466466 Text en Copyright © 2007 Hsieh et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Hsieh, Hsin-Ju
Palmer, Christina GS
Harney, Sinead
Chen, Hsiu-Wen
Bauman, Lara
Brown, Matthew A
Sinsheimer, Janet S
Using the maternal-fetal genotype incompatibility test to assess non-inherited maternal HLA-DRB1 antigen coding alleles as rheumatoid arthritis risk factors
title Using the maternal-fetal genotype incompatibility test to assess non-inherited maternal HLA-DRB1 antigen coding alleles as rheumatoid arthritis risk factors
title_full Using the maternal-fetal genotype incompatibility test to assess non-inherited maternal HLA-DRB1 antigen coding alleles as rheumatoid arthritis risk factors
title_fullStr Using the maternal-fetal genotype incompatibility test to assess non-inherited maternal HLA-DRB1 antigen coding alleles as rheumatoid arthritis risk factors
title_full_unstemmed Using the maternal-fetal genotype incompatibility test to assess non-inherited maternal HLA-DRB1 antigen coding alleles as rheumatoid arthritis risk factors
title_short Using the maternal-fetal genotype incompatibility test to assess non-inherited maternal HLA-DRB1 antigen coding alleles as rheumatoid arthritis risk factors
title_sort using the maternal-fetal genotype incompatibility test to assess non-inherited maternal hla-drb1 antigen coding alleles as rheumatoid arthritis risk factors
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367472/
https://www.ncbi.nlm.nih.gov/pubmed/18466466
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