Power of the 2-locus TDT for testing the interaction of two susceptibility genes

We recently proposed a new strategy: 2-locus TDT for detecting two susceptibility genes through their interaction in trio families. We apply our method to two candidate genes, A and C, on the Genetic Analysis Workshop 15 (GAW15) simulated rheumatoid arthritis data and study the power to identify an...

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Detalles Bibliográficos
Autores principales: Kotti, Salma, Bourgey, Mathieu, Clerget-Darpoux, Françoise
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367511/
https://www.ncbi.nlm.nih.gov/pubmed/18466566
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author Kotti, Salma
Bourgey, Mathieu
Clerget-Darpoux, Françoise
author_facet Kotti, Salma
Bourgey, Mathieu
Clerget-Darpoux, Françoise
author_sort Kotti, Salma
collection PubMed
description We recently proposed a new strategy: 2-locus TDT for detecting two susceptibility genes through their interaction in trio families. We apply our method to two candidate genes, A and C, on the Genetic Analysis Workshop 15 (GAW15) simulated rheumatoid arthritis data and study the power to identify an interactive effect of these genes. This study was performed with full knowledge of the answers.
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spelling pubmed-23675112008-05-06 Power of the 2-locus TDT for testing the interaction of two susceptibility genes Kotti, Salma Bourgey, Mathieu Clerget-Darpoux, Françoise BMC Proc Proceedings We recently proposed a new strategy: 2-locus TDT for detecting two susceptibility genes through their interaction in trio families. We apply our method to two candidate genes, A and C, on the Genetic Analysis Workshop 15 (GAW15) simulated rheumatoid arthritis data and study the power to identify an interactive effect of these genes. This study was performed with full knowledge of the answers. BioMed Central 2007-12-18 /pmc/articles/PMC2367511/ /pubmed/18466566 Text en Copyright © 2007 Kotti et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Kotti, Salma
Bourgey, Mathieu
Clerget-Darpoux, Françoise
Power of the 2-locus TDT for testing the interaction of two susceptibility genes
title Power of the 2-locus TDT for testing the interaction of two susceptibility genes
title_full Power of the 2-locus TDT for testing the interaction of two susceptibility genes
title_fullStr Power of the 2-locus TDT for testing the interaction of two susceptibility genes
title_full_unstemmed Power of the 2-locus TDT for testing the interaction of two susceptibility genes
title_short Power of the 2-locus TDT for testing the interaction of two susceptibility genes
title_sort power of the 2-locus tdt for testing the interaction of two susceptibility genes
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367511/
https://www.ncbi.nlm.nih.gov/pubmed/18466566
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