Comparison of multipoint linkage analyses for quantitative traits in the CEPH data: parametric LOD scores, variance components LOD scores, and Bayes factors

We performed multipoint linkage analyses with multiple programs and models for several gene expression traits in the Centre d'Etude du Polymorphisme Humain families. All analyses provided consistent results for both peak location and shape. Variance-components (VC) analysis gave wider peaks and...

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Autores principales: Sung, Yun Ju, Di, Yanming, Fu, Audrey Q, Rothstein, Joseph H, Sieh, Weiva, Tong, Liping, Thompson, Elizabeth A, Wijsman, Ellen M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367516/
https://www.ncbi.nlm.nih.gov/pubmed/18466597
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author Sung, Yun Ju
Di, Yanming
Fu, Audrey Q
Rothstein, Joseph H
Sieh, Weiva
Tong, Liping
Thompson, Elizabeth A
Wijsman, Ellen M
author_facet Sung, Yun Ju
Di, Yanming
Fu, Audrey Q
Rothstein, Joseph H
Sieh, Weiva
Tong, Liping
Thompson, Elizabeth A
Wijsman, Ellen M
author_sort Sung, Yun Ju
collection PubMed
description We performed multipoint linkage analyses with multiple programs and models for several gene expression traits in the Centre d'Etude du Polymorphisme Humain families. All analyses provided consistent results for both peak location and shape. Variance-components (VC) analysis gave wider peaks and Bayes factors gave fewer peaks. Among programs from the MORGAN package, lm_multiple performed better than lm_markers, resulting in less Markov-chain Monte Carlo (MCMC) variability between runs, and the program lm_twoqtl provided higher LOD scores by also including either a polygenic component or an additional quantitative trait locus.
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spelling pubmed-23675162008-05-06 Comparison of multipoint linkage analyses for quantitative traits in the CEPH data: parametric LOD scores, variance components LOD scores, and Bayes factors Sung, Yun Ju Di, Yanming Fu, Audrey Q Rothstein, Joseph H Sieh, Weiva Tong, Liping Thompson, Elizabeth A Wijsman, Ellen M BMC Proc Proceedings We performed multipoint linkage analyses with multiple programs and models for several gene expression traits in the Centre d'Etude du Polymorphisme Humain families. All analyses provided consistent results for both peak location and shape. Variance-components (VC) analysis gave wider peaks and Bayes factors gave fewer peaks. Among programs from the MORGAN package, lm_multiple performed better than lm_markers, resulting in less Markov-chain Monte Carlo (MCMC) variability between runs, and the program lm_twoqtl provided higher LOD scores by also including either a polygenic component or an additional quantitative trait locus. BioMed Central 2007-12-18 /pmc/articles/PMC2367516/ /pubmed/18466597 Text en Copyright © 2007 Sung et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Sung, Yun Ju
Di, Yanming
Fu, Audrey Q
Rothstein, Joseph H
Sieh, Weiva
Tong, Liping
Thompson, Elizabeth A
Wijsman, Ellen M
Comparison of multipoint linkage analyses for quantitative traits in the CEPH data: parametric LOD scores, variance components LOD scores, and Bayes factors
title Comparison of multipoint linkage analyses for quantitative traits in the CEPH data: parametric LOD scores, variance components LOD scores, and Bayes factors
title_full Comparison of multipoint linkage analyses for quantitative traits in the CEPH data: parametric LOD scores, variance components LOD scores, and Bayes factors
title_fullStr Comparison of multipoint linkage analyses for quantitative traits in the CEPH data: parametric LOD scores, variance components LOD scores, and Bayes factors
title_full_unstemmed Comparison of multipoint linkage analyses for quantitative traits in the CEPH data: parametric LOD scores, variance components LOD scores, and Bayes factors
title_short Comparison of multipoint linkage analyses for quantitative traits in the CEPH data: parametric LOD scores, variance components LOD scores, and Bayes factors
title_sort comparison of multipoint linkage analyses for quantitative traits in the ceph data: parametric lod scores, variance components lod scores, and bayes factors
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367516/
https://www.ncbi.nlm.nih.gov/pubmed/18466597
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