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An ordered subset approach to including covariates in the transmission disequilibrium test

Clinical heterogeneity of a disease may reflect an underlying genetic heterogeneity, which may hinder the detection of trait loci. Consequently, many statistical methods have been developed that allow for the detection of linkage and/or association signals in the presence of heterogeneity. This repo...

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Autores principales: Perdry, Hervé, Maher, Brion S, Babron, Marie-Claude, McHenry, Toby, Clerget-Darpoux, Françoise, Marazita, Mary L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367525/
https://www.ncbi.nlm.nih.gov/pubmed/18466579
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author Perdry, Hervé
Maher, Brion S
Babron, Marie-Claude
McHenry, Toby
Clerget-Darpoux, Françoise
Marazita, Mary L
author_facet Perdry, Hervé
Maher, Brion S
Babron, Marie-Claude
McHenry, Toby
Clerget-Darpoux, Françoise
Marazita, Mary L
author_sort Perdry, Hervé
collection PubMed
description Clinical heterogeneity of a disease may reflect an underlying genetic heterogeneity, which may hinder the detection of trait loci. Consequently, many statistical methods have been developed that allow for the detection of linkage and/or association signals in the presence of heterogeneity. This report describes the work of two parallel investigations into similar approaches to ordered subset analysis, based on an observed covariate, in the framework of family-based association analysis using Genetic Analysis Workshop 15 simulated data. With an appropriate choice of covariate, both approaches allow detection of two loci that are undetectable by the classical transmission-disequilibrium test. For a third locus, detectable by the classical transmission-disequilibrium test, a substantial increase of power of detection is shown.
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spelling pubmed-23675252008-05-06 An ordered subset approach to including covariates in the transmission disequilibrium test Perdry, Hervé Maher, Brion S Babron, Marie-Claude McHenry, Toby Clerget-Darpoux, Françoise Marazita, Mary L BMC Proc Proceedings Clinical heterogeneity of a disease may reflect an underlying genetic heterogeneity, which may hinder the detection of trait loci. Consequently, many statistical methods have been developed that allow for the detection of linkage and/or association signals in the presence of heterogeneity. This report describes the work of two parallel investigations into similar approaches to ordered subset analysis, based on an observed covariate, in the framework of family-based association analysis using Genetic Analysis Workshop 15 simulated data. With an appropriate choice of covariate, both approaches allow detection of two loci that are undetectable by the classical transmission-disequilibrium test. For a third locus, detectable by the classical transmission-disequilibrium test, a substantial increase of power of detection is shown. BioMed Central 2007-12-18 /pmc/articles/PMC2367525/ /pubmed/18466579 Text en Copyright © 2007 Perdry et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Perdry, Hervé
Maher, Brion S
Babron, Marie-Claude
McHenry, Toby
Clerget-Darpoux, Françoise
Marazita, Mary L
An ordered subset approach to including covariates in the transmission disequilibrium test
title An ordered subset approach to including covariates in the transmission disequilibrium test
title_full An ordered subset approach to including covariates in the transmission disequilibrium test
title_fullStr An ordered subset approach to including covariates in the transmission disequilibrium test
title_full_unstemmed An ordered subset approach to including covariates in the transmission disequilibrium test
title_short An ordered subset approach to including covariates in the transmission disequilibrium test
title_sort ordered subset approach to including covariates in the transmission disequilibrium test
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367525/
https://www.ncbi.nlm.nih.gov/pubmed/18466579
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