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Novel integrative genomics strategies to identify genes for complex traits
Forward genetics is a common approach to dissecting complex traits like common human diseases. The ultimate aim of this approach was the identification of genes that are causal for disease or other phenotypes of interest. However, the forward genetics approach is by definition restricted to the iden...
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Formato: | Texto |
Lenguaje: | English |
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Blackwell Publishing Ltd
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367618/ https://www.ncbi.nlm.nih.gov/pubmed/16886998 http://dx.doi.org/10.1111/j.1365-2052.2006.01473.x |
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author | Schadt, E E |
author_facet | Schadt, E E |
author_sort | Schadt, E E |
collection | PubMed |
description | Forward genetics is a common approach to dissecting complex traits like common human diseases. The ultimate aim of this approach was the identification of genes that are causal for disease or other phenotypes of interest. However, the forward genetics approach is by definition restricted to the identification of genes that have incurred mutations over the course of evolution or that incurred mutations as a result of chemical mutagenesis, and that as a result lead to disease or to variations in other phenotypes of interest. Genes that harbour no such mutations, but that play key roles in parts of the biological network that lead to disease, are systematically missed by this class of approaches. Recently, a class of novel integrative genomics approaches has been devised to elucidate the complexity of common human diseases by intersecting genotypic, molecular profiling, and clinical data in segregating populations. These novel approaches take a more holistic view of biological systems and leverage the vast network of gene–gene interactions, in combination with DNA variation data, to establish causal relationships among molecular profiling traits and Fbetween molecular profiling and disease (or other classic phenotypes). A number of novel genes for disease phenotypes have been identified as a result of these approaches, highlighting the utility of integrating orthogonal sources of data to get at the underlying causes of disease. |
format | Text |
id | pubmed-2367618 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-23676182008-05-06 Novel integrative genomics strategies to identify genes for complex traits Schadt, E E Anim Genet Short Communications Forward genetics is a common approach to dissecting complex traits like common human diseases. The ultimate aim of this approach was the identification of genes that are causal for disease or other phenotypes of interest. However, the forward genetics approach is by definition restricted to the identification of genes that have incurred mutations over the course of evolution or that incurred mutations as a result of chemical mutagenesis, and that as a result lead to disease or to variations in other phenotypes of interest. Genes that harbour no such mutations, but that play key roles in parts of the biological network that lead to disease, are systematically missed by this class of approaches. Recently, a class of novel integrative genomics approaches has been devised to elucidate the complexity of common human diseases by intersecting genotypic, molecular profiling, and clinical data in segregating populations. These novel approaches take a more holistic view of biological systems and leverage the vast network of gene–gene interactions, in combination with DNA variation data, to establish causal relationships among molecular profiling traits and Fbetween molecular profiling and disease (or other classic phenotypes). A number of novel genes for disease phenotypes have been identified as a result of these approaches, highlighting the utility of integrating orthogonal sources of data to get at the underlying causes of disease. Blackwell Publishing Ltd 2006-08 /pmc/articles/PMC2367618/ /pubmed/16886998 http://dx.doi.org/10.1111/j.1365-2052.2006.01473.x Text en © 2006 The Authors, Journal compilation © 2006 International Society for Animal Genetics https://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
spellingShingle | Short Communications Schadt, E E Novel integrative genomics strategies to identify genes for complex traits |
title | Novel integrative genomics strategies to identify genes for complex traits |
title_full | Novel integrative genomics strategies to identify genes for complex traits |
title_fullStr | Novel integrative genomics strategies to identify genes for complex traits |
title_full_unstemmed | Novel integrative genomics strategies to identify genes for complex traits |
title_short | Novel integrative genomics strategies to identify genes for complex traits |
title_sort | novel integrative genomics strategies to identify genes for complex traits |
topic | Short Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367618/ https://www.ncbi.nlm.nih.gov/pubmed/16886998 http://dx.doi.org/10.1111/j.1365-2052.2006.01473.x |
work_keys_str_mv | AT schadtee novelintegrativegenomicsstrategiestoidentifygenesforcomplextraits |