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Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase γ replication fidelity

Replication of the mitochondrial genome by DNA polymerase γ requires dNTP precursors that are subject to oxidation by reactive oxygen species generated by the mitochondrial respiratory chain. One such oxidation product is 8-oxo-dGTP, which can compete with dTTP for incorporation opposite template ad...

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Detalles Bibliográficos
Autores principales:	Pursell, Zachary F., McDonald, J. Tyson, Mathews, Christopher K., Kunkel, Thomas A.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367704/ https://www.ncbi.nlm.nih.gov/pubmed/18276636 http://dx.doi.org/10.1093/nar/gkn062

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