Eukaryotic Y-family polymerases bypass a 3-methyl-2′-deoxyadenosine analog in vitro and methyl methanesulfonate-induced DNA damage in vivo

N3-methyl-adenine (3MeA) is the major cytotoxic lesion formed in DNA by S(N)2 methylating agents. The lesion presumably blocks progression of cellular replicases because the N3-methyl group hinders interactions between the polymerase and the minor groove of DNA. However, this hypothesis has yet to b...

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Detalles Bibliográficos
Autores principales: Plosky, Brian S., Frank, Ekaterina G., Berry, David A., Vennall, Graham P., McDonald, John P., Woodgate, Roger
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367705/
https://www.ncbi.nlm.nih.gov/pubmed/18281311
http://dx.doi.org/10.1093/nar/gkn058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367705/
https://www.ncbi.nlm.nih.gov/pubmed/18281311
http://dx.doi.org/10.1093/nar/gkn058

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