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Epigenetics of a tandem DNA repeat: chromatin DNaseI sensitivity and opposite methylation changes in cancers

DNA methylation and chromatin DNaseI sensitivity were analyzed in and adjacent to D4Z4 repeat arrays, which consist of 1 to ∼100 tandem 3.3-kb units at subtelomeric 4q and 10q. D4Z4 displayed hypomethylation in some cancers and hypermethylation in others relative to normal tissues. Surprisingly, in...

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Detalles Bibliográficos
Autores principales:	Tsumagari, Koji, Qi, Lixin, Jackson, Kesmic, Shao, Chunbo, Lacey, Michelle, Sowden, Janet, Tawil, Rabi, Vedanarayanan, Vettaikorumakankav, Ehrlich, Melanie
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367708/ https://www.ncbi.nlm.nih.gov/pubmed/18281700 http://dx.doi.org/10.1093/nar/gkn055

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