Position effect variegation and imprinting of transgenes in lymphocytes

Sequences proximal to transgene integration sites are able to deregulate transgene expression resulting in complex position effect phenotypes. In addition, transgenes integrated as repeated arrays are susceptible to repeat-induced gene silencing. Using a Cre recombinase-based system we have addresse...

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Detalles Bibliográficos
Autores principales: Williams, Adam, Harker, Nicola, Ktistaki, Eleni, Veiga-Fernandes, Henrique, Roderick, Kathleen, Tolaini, Mauro, Norton, Trisha, Williams, Keith, Kioussis, Dimitris
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367730/
https://www.ncbi.nlm.nih.gov/pubmed/18296483
http://dx.doi.org/10.1093/nar/gkn085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367730/
https://www.ncbi.nlm.nih.gov/pubmed/18296483
http://dx.doi.org/10.1093/nar/gkn085

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