Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course

Immunotherapy of feline immunodeficiency virus (FIV)-infected cats with monocyte-derived dendritic cells (MDCs) loaded with aldrithiol-2 (AT2)-inactivated homologous FIV was performed. Although FIV-specific lymphoproliferative responses were markedly increased, viral loads and CD4(+ )T cell depletio...

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Detalles Bibliográficos
Autores principales: Freer, Giulia, Matteucci, Donatella, Mazzetti, Paola, Tarabella, Francesca, Ricci, Enrica, Bozzacco, Leonia, Merico, Antonio, Pistello, Mauro, Ceccherini-Nelli, Luca, Bendinelli, Mauro
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373306/
https://www.ncbi.nlm.nih.gov/pubmed/18416857
http://dx.doi.org/10.1186/1742-4690-5-33
Descripción
Sumario:Immunotherapy of feline immunodeficiency virus (FIV)-infected cats with monocyte-derived dendritic cells (MDCs) loaded with aldrithiol-2 (AT2)-inactivated homologous FIV was performed. Although FIV-specific lymphoproliferative responses were markedly increased, viral loads and CD4(+ )T cell depletion were unaffected, thus indicating that boosting antiviral cell-mediated immunity may not suffice to modify infection course appreciably.

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