Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course

Immunotherapy of feline immunodeficiency virus (FIV)-infected cats with monocyte-derived dendritic cells (MDCs) loaded with aldrithiol-2 (AT2)-inactivated homologous FIV was performed. Although FIV-specific lymphoproliferative responses were markedly increased, viral loads and CD4(+ )T cell depletio...

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Autores principales: Freer, Giulia, Matteucci, Donatella, Mazzetti, Paola, Tarabella, Francesca, Ricci, Enrica, Bozzacco, Leonia, Merico, Antonio, Pistello, Mauro, Ceccherini-Nelli, Luca, Bendinelli, Mauro
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373306/
https://www.ncbi.nlm.nih.gov/pubmed/18416857
http://dx.doi.org/10.1186/1742-4690-5-33
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author Freer, Giulia
Matteucci, Donatella
Mazzetti, Paola
Tarabella, Francesca
Ricci, Enrica
Bozzacco, Leonia
Merico, Antonio
Pistello, Mauro
Ceccherini-Nelli, Luca
Bendinelli, Mauro
author_facet Freer, Giulia
Matteucci, Donatella
Mazzetti, Paola
Tarabella, Francesca
Ricci, Enrica
Bozzacco, Leonia
Merico, Antonio
Pistello, Mauro
Ceccherini-Nelli, Luca
Bendinelli, Mauro
author_sort Freer, Giulia
collection PubMed
description Immunotherapy of feline immunodeficiency virus (FIV)-infected cats with monocyte-derived dendritic cells (MDCs) loaded with aldrithiol-2 (AT2)-inactivated homologous FIV was performed. Although FIV-specific lymphoproliferative responses were markedly increased, viral loads and CD4(+ )T cell depletion were unaffected, thus indicating that boosting antiviral cell-mediated immunity may not suffice to modify infection course appreciably.
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spelling pubmed-23733062008-05-07 Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course Freer, Giulia Matteucci, Donatella Mazzetti, Paola Tarabella, Francesca Ricci, Enrica Bozzacco, Leonia Merico, Antonio Pistello, Mauro Ceccherini-Nelli, Luca Bendinelli, Mauro Retrovirology Short Report Immunotherapy of feline immunodeficiency virus (FIV)-infected cats with monocyte-derived dendritic cells (MDCs) loaded with aldrithiol-2 (AT2)-inactivated homologous FIV was performed. Although FIV-specific lymphoproliferative responses were markedly increased, viral loads and CD4(+ )T cell depletion were unaffected, thus indicating that boosting antiviral cell-mediated immunity may not suffice to modify infection course appreciably. BioMed Central 2008-04-17 /pmc/articles/PMC2373306/ /pubmed/18416857 http://dx.doi.org/10.1186/1742-4690-5-33 Text en Copyright © 2008 Freer et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Freer, Giulia
Matteucci, Donatella
Mazzetti, Paola
Tarabella, Francesca
Ricci, Enrica
Bozzacco, Leonia
Merico, Antonio
Pistello, Mauro
Ceccherini-Nelli, Luca
Bendinelli, Mauro
Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course
title Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course
title_full Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course
title_fullStr Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course
title_full_unstemmed Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course
title_short Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course
title_sort immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373306/
https://www.ncbi.nlm.nih.gov/pubmed/18416857
http://dx.doi.org/10.1186/1742-4690-5-33
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