Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cγ at the centrosome

BACKGROUND: The t(6;8) translocation found in rare and agressive myeloproliferative disorders results in a chimeric gene encoding the FOP-FGFR1 fusion protein. This protein comprises the N-terminal region of the centrosomal protein FOP and the tyrosine kinase of the FGFR1 receptor. FOP-FGFR1 is loca...

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Detalles Bibliográficos
Autores principales: Lelièvre, Hélène, Chevrier, Véronique, Tassin, Anne-Marie, Birnbaum, Daniel
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373309/
https://www.ncbi.nlm.nih.gov/pubmed/18412956
http://dx.doi.org/10.1186/1476-4598-7-30

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