DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication

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DNA and histone synthesis are coupled and ongoing replication is required to maintain histone gene expression. Here, we expose S phase–arrested cells to the kinase inhibitors caffeine and LY294002. This uncouples DNA replication from histone messenger RNA (mRNA) abundance, altering the efficiency of...

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Detalles Bibliográficos
Autores principales: Müller, Berndt, Blackburn, Jane, Feijoo, Carmen, Zhao, Xiujie, Smythe, Carl
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373486/
https://www.ncbi.nlm.nih.gov/pubmed/18158334
http://dx.doi.org/10.1083/jcb.200708106

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