Crippling HIV one mutation at a time

Accumulating data suggest that not all human immunodeficiency virus (HIV)-1–specific immune responses are equally effective at controlling HIV-1 replication. A new study now demonstrates that multiple immune-driven sequence polymorphisms in the highly conserved HIV-1 Gag region of transmitted viruse...

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Detalles Bibliográficos
Autores principales: Allen, Todd M., Altfeld, Marcus
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373833/
https://www.ncbi.nlm.nih.gov/pubmed/18458116
http://dx.doi.org/10.1084/jem.20080569
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author Allen, Todd M.
Altfeld, Marcus
author_facet Allen, Todd M.
Altfeld, Marcus
author_sort Allen, Todd M.
collection PubMed
description Accumulating data suggest that not all human immunodeficiency virus (HIV)-1–specific immune responses are equally effective at controlling HIV-1 replication. A new study now demonstrates that multiple immune-driven sequence polymorphisms in the highly conserved HIV-1 Gag region of transmitted viruses are associated with reduced viral replication in newly infected humans. These data suggest that targeting these and other conserved viral regions may be the key to developing an effective HIV-1 vaccine.
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spelling pubmed-23738332008-11-12 Crippling HIV one mutation at a time Allen, Todd M. Altfeld, Marcus J Exp Med Commentaries Accumulating data suggest that not all human immunodeficiency virus (HIV)-1–specific immune responses are equally effective at controlling HIV-1 replication. A new study now demonstrates that multiple immune-driven sequence polymorphisms in the highly conserved HIV-1 Gag region of transmitted viruses are associated with reduced viral replication in newly infected humans. These data suggest that targeting these and other conserved viral regions may be the key to developing an effective HIV-1 vaccine. The Rockefeller University Press 2008-05-12 /pmc/articles/PMC2373833/ /pubmed/18458116 http://dx.doi.org/10.1084/jem.20080569 Text en Copyright © 2008, The Rockefeller University Press https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Allen, Todd M.
Altfeld, Marcus
Crippling HIV one mutation at a time
title Crippling HIV one mutation at a time
title_full Crippling HIV one mutation at a time
title_fullStr Crippling HIV one mutation at a time
title_full_unstemmed Crippling HIV one mutation at a time
title_short Crippling HIV one mutation at a time
title_sort crippling hiv one mutation at a time
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373833/
https://www.ncbi.nlm.nih.gov/pubmed/18458116
http://dx.doi.org/10.1084/jem.20080569
work_keys_str_mv AT allentoddm cripplinghivonemutationatatime
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