Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients

In a study of 114 epidemiologically linked Zambian transmission pairs, we evaluated the impact of human leukocyte antigen class I (HLA-I)–associated amino acid polymorphisms, presumed to reflect cytotoxic T lymphocyte (CTL) escape in Gag and Nef of the virus transmitted from the chronically infected...

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Detalles Bibliográficos
Autores principales: Goepfert, Paul A., Lumm, Wendy, Farmer, Paul, Matthews, Philippa, Prendergast, Andrew, Carlson, Jonathan M., Derdeyn, Cynthia A., Tang, Jianming, Kaslow, Richard A., Bansal, Anju, Yusim, Karina, Heckerman, David, Mulenga, Joseph, Allen, Susan, Goulder, Philip J.R., Hunter, Eric
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373834/
https://www.ncbi.nlm.nih.gov/pubmed/18426987
http://dx.doi.org/10.1084/jem.20072457

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