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IL-6–dependent spontaneous proliferation is required for the induction of colitogenic IL-17–producing CD8(+) T cells

We propose a novel role for interleukin (IL) 6 in inducing rapid spontaneous proliferation (SP) of naive CD8(+) T cells, which is a crucial step in the differentiation of colitogenic CD8(+) T cells. Homeostasis of T cells is regulated by two distinct modes of cell proliferation: major histocompatibi...

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Detalles Bibliográficos
Autores principales:	Tajima, Masaki, Wakita, Daiko, Noguchi, Daisuke, Chamoto, Kenji, Yue, Zhang, Fugo, Kazunori, Ishigame, Harumichi, Iwakura, Yoichiro, Kitamura, Hidemitsu, Nishimura, Takashi
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Brief Definitive Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373835/ https://www.ncbi.nlm.nih.gov/pubmed/18426983 http://dx.doi.org/10.1084/jem.20071133

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