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During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain
Apoptosis accompanying negative selection is a central but poorly understood event in T cell development. The Nur77 nuclear steroid receptor and Bim, a proapoptotic BH3-only member of the Bcl-2 family, are two molecules implicated in this process. However, how they relate to each other and how Nur77...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373836/ https://www.ncbi.nlm.nih.gov/pubmed/18443228 http://dx.doi.org/10.1084/jem.20080101 |