Cargando…

IL-15Rα chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation

Natural killer (NK) cells are innate immune effectors that mediate rapid responses to viral antigens. Interleukin (IL)-15 and its high affinity IL-15 receptor, IL-15Rα, support NK cell homeostasis in resting animals via a novel trans presentation mechanism. To better understand how IL-15 and IL-15Rα...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mortier, Erwan, Woo, Tammy, Advincula, Rommel, Gozalo, Sara, Ma, Averil
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373851/ https://www.ncbi.nlm.nih.gov/pubmed/18458113 http://dx.doi.org/10.1084/jem.20071913

Ejemplares similares

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo
por: Huntington, Nicholas D., et al.
Publicado: (2009)

Coordinate Expression and Trans Presentation of Interleukin (IL)-15Rα and IL-15 Supports Natural Killer Cell and Memory CD8(+) T Cell Homeostasis
por: Burkett, Patrick R., et al.
Publicado: (2004)

Development of Stable Chimeric IL-15 for Trans-Presentation by the Antigen Presenting Cells
por: Patidar, Manoj, et al.
Publicado: (2021)

Interleukin (IL)-15Rα–deficient Natural Killer Cells Survive in Normal but Not IL-15Rα–deficient Mice
por: Koka, Rima, et al.
Publicado: (2003)

Interleukin-15 Dendritic Cells Harness NK Cell Cytotoxic Effector Function in a Contact- and IL-15-Dependent Manner
por: Anguille, Sébastien, et al.
Publicado: (2015)

NK Cell Activation in Human Hantavirus Infection Explained by Virus-Induced IL-15/IL15Rα Expression
por: Braun, Monika, et al.
Publicado: (2014)

Selective Targeting of IL-15Rα Is Sufficient to Reduce Inflammation
por: Meghnem, Dihia, et al.
Publicado: (2022)

Cetuximab and IL-15 Promote NK and Dendritic Cell Activation In Vitro in Triple Negative Breast Cancer
por: Juliá, Estefanía Paula, et al.
Publicado: (2020)

IL-15Rα-Independent IL-15 Signaling in Non-NK Cell-Derived IFNγ Driven Control of Listeria monocytogenes
por: Nandi, Madhuparna, et al.
Publicado: (2021)

Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo
por: Silvestre, Renata Nacasaki, et al.
Publicado: (2023)

NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation
por: Clark, Sarah E., et al.
Publicado: (2019)

Transpresentation of interleukin-15 by IL-15/IL-15Rα mRNA-engineered human dendritic cells boosts antitumoral natural killer cell activity
por: Van den Bergh, Johan, et al.
Publicado: (2015)

IL-15 Promotes Polyfunctional NK Cell Responses to Influenza by Boosting IL-12 Production
por: Wagstaffe, Helen R., et al.
Publicado: (2018)

IL-15/IL-15Rα in SJS/TEN: Relevant Expression of IL15 and IL15RA in Affected Skin
por: Bellón, Teresa, et al.
Publicado: (2022)

IL-15 Overcomes Hepatocellular Carcinoma-Induced NK Cell Dysfunction
por: Easom, Nicholas J. W., et al.
Publicado: (2018)

Comparison of characteristics and tumor targeting properties of extracellular vesicles derived from primary NK cells or NK-cell lines stimulated with IL-15 or IL-12/15/18
por: Aarsund, Miriam, et al.
Publicado: (2022)

Out-sourcing for Trans-presentation: Assessing T Cell Intrinsic and Extrinsic IL-15 Expression with Il15 Gene Reporter Mice
por: Park, Joo-Young, et al.
Publicado: (2018)

Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapse
por: Beilin, Chiara, et al.
Publicado: (2018)

Mechanistic and Structural Insights on the IL-15 System through Molecular Dynamics Simulations
por: Sousa, Rui P., et al.
Publicado: (2019)

Activation of ADAM17 by IL-15 Limits Human NK Cell Proliferation
por: Mishra, Hemant K., et al.
Publicado: (2021)

IL-18, but not IL-15, contributes to the IL-12-dependent induction of NK-cell effector functions by Leishmania infantum in vivo
por: Haeberlein, Simone, et al.
Publicado: (2010)

STAT3 governs the HIF-1α response in IL-15 primed human NK cells
por: Coulibaly, Anna, et al.
Publicado: (2021)

Transcription Factors Associated With IL-15 Cytokine Signaling During NK Cell Development
por: Wang, Xiang, et al.
Publicado: (2021)

Myc controls NK cell development, IL-15-driven expansion, and translational machinery
por: Khameneh, Hanif J, et al.
Publicado: (2023)

IL-12/15/18-induced cell death and mitochondrial dynamics of human NK cells
por: Terrén, Iñigo, et al.
Publicado: (2023)

A Chimeric IL-15/IL-15Rα Molecule Expressed on NFκB-Activated Dendritic Cells Supports Their Capability to Activate Natural Killer Cells †
por: Bosch, Naomi C., et al.
Publicado: (2021)

IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas
por: Kim, Peter S., et al.
Publicado: (2016)

IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection
por: McGill, Jodi, et al.
Publicado: (2010)

Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice
por: Matsuda, Masashi, et al.
Publicado: (2019)

Electrotransfer of IL-15/IL-15Rα complex for the treatment of established melanoma
por: Shirley, Shawna, et al.
Publicado: (2015)

Electrotransfer of IL-15/IL-15Rα Complex for the Treatment of Established Melanoma
por: Shirley, Shawna A., et al.
Publicado: (2020)

In vitro modelling of local gene therapy with IL-15/IL-15Rα and a PD-L1 antagonist in melanoma reveals an interplay between NK cells and CD4(+) T cells
por: Awad, Robin Maximilian, et al.
Publicado: (2023)

Chemotherapy-resistant osteosarcoma is highly susceptible to IL-15-activated allogeneic and autologous NK cells
por: Buddingh, Emilie P., et al.
Publicado: (2011)

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells
por: Niogret, Charlène, et al.
Publicado: (2019)

Functional enhancement of exosomes derived from NK cells by IL-15 and IL-21 synergy against hepatocellular carcinoma cells: The cytotoxicity and apoptosis in vitro study
por: Kim, In-Young, et al.
Publicado: (2023)

Targeted cancer immunotherapy: Mimicking physiological trans-presentation of IL-15
por: Müller, Dafne
Publicado: (2012)

Vaccination with Tumor Cells Expressing IL-15 and IL-15Rα Inhibit Murine Breast and Prostate Cancer
por: Morris, John C., et al.
Publicado: (2014)

Selective costimulation by IL-15R/IL-15, but not IL-2R/IL-2, allows the induction of high numbers of tumor-specific CD8+ T cells by human dendritic cells matured in conditions of acute inflammation
por: Hansen, Morten, et al.
Publicado: (2015)

Interleukin-15-Cultured Dendritic Cells Enhance Anti-Tumor Gamma Delta T Cell Functions through IL-15 Secretion
por: Van Acker, Heleen H., et al.
Publicado: (2018)

Phenotypic and Functional Dysregulated Blood NK Cells in Colorectal Cancer Patients Can Be Activated by Cetuximab Plus IL-2 or IL-15
por: Rocca, Yamila Sol, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_1o0ptp7ksuvfaq2iijem5tlgvr