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Analysis of correlated mutations in HIV-1 protease using spectral clustering

Motivation: The ability of human immunodeficiency virus-1 (HIV-1) protease to develop mutations that confer multi-drug resistance (MDR) has been a major obstacle in designing rational therapies against HIV. Resistance is usually imparted by a cooperative mechanism that can be elucidated by a covaria...

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Detalles Bibliográficos
Autores principales:	Liu, Ying, Eyal, Eran, Bahar, Ivet
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373918/ https://www.ncbi.nlm.nih.gov/pubmed/18375964 http://dx.doi.org/10.1093/bioinformatics/btn110

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