Enhancement of Allele Discrimination by Introduction of Nucleotide Mismatches into siRNA in Allele-Specific Gene Silencing by RNAi

Allele-specific gene silencing by RNA interference (RNAi) is therapeutically useful for specifically inhibiting the expression of disease-associated alleles without suppressing the expression of corresponding wild-type alleles. To realize such allele-specific RNAi (ASP-RNAi), the design and assessme...

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Detalles Bibliográficos
Autores principales: Ohnishi, Yusuke, Tamura, Yoshiko, Yoshida, Mariko, Tokunaga, Katsushi, Hohjoh, Hirohiko
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373929/
https://www.ncbi.nlm.nih.gov/pubmed/18493311
http://dx.doi.org/10.1371/journal.pone.0002248

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