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Experimental designs for phase I and phase I/II dose-finding studies
We review the rationale behind the statistical design of dose-finding studies as used in phase I and phase I/II clinical trials. We underline what the objectives of such dose-finding studies should be and why the widely used standard design fails to meet any of these objectives. The standard design...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374235/ https://www.ncbi.nlm.nih.gov/pubmed/16434987 http://dx.doi.org/10.1038/sj.bjc.6602969 |