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Chromosome alterations and E-cadherin gene mutations in human lobular breast cancer

We have studied a set of 40 human lobular breast cancers for loss of heterozygosity (LOH) at various chromosome locations and for mutations in the coding region plus flanking intron sequences of the E-cadherin gene. We found a high frequency of LOH (100%, 31/31) at 16q21–q22.1. A significantly highe...

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Detalles Bibliográficos
Autores principales:	Huiping, C, Sigurgeirsdottir, J R, Jonasson, J G, Eiriksdottir, G, Johannsdottir, J T, Egilsson, V, Ingvarsson, S
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1999
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374316/ https://www.ncbi.nlm.nih.gov/pubmed/10584868 http://dx.doi.org/10.1038/sj.bjc.6690815

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