Expression of testicular genes in haematological malignancies

The gene expression of a new group of tumour antigens known as cancer/testis (CT) antigens is now well-recognized in some solid tumours. However, their expression in haematological malignancies remained unclear. In this study, we have used reverse transcription polymerase chain reaction and Southern...

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Autores principales: Lim, S H, Austin, S, Owen-Jones, E, Robinson, L
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374325/
https://www.ncbi.nlm.nih.gov/pubmed/10584877
http://dx.doi.org/10.1038/sj.bjc.6690824
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author Lim, S H
Austin, S
Owen-Jones, E
Robinson, L
author_facet Lim, S H
Austin, S
Owen-Jones, E
Robinson, L
author_sort Lim, S H
collection PubMed
description The gene expression of a new group of tumour antigens known as cancer/testis (CT) antigens is now well-recognized in some solid tumours. However, their expression in haematological malignancies remained unclear. In this study, we have used reverse transcription polymerase chain reaction and Southern blot analysis to examine the presence of transcripts for the three CT antigens, NY-ESO-1, SSX2 and SCP1 in haematological malignant cells. We found that transcripts for SCP1 could be detected in 10% of myeloma, 5.7% of acute myeloid leukaemia and 23% of chronic myeloid leukaemia. In contrast, NY-ESO-1 and SSX2 were not detected in any of the 107 tumour samples. © 1999 Cancer Research Campaign
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spelling pubmed-23743252009-09-10 Expression of testicular genes in haematological malignancies Lim, S H Austin, S Owen-Jones, E Robinson, L Br J Cancer Regular Article The gene expression of a new group of tumour antigens known as cancer/testis (CT) antigens is now well-recognized in some solid tumours. However, their expression in haematological malignancies remained unclear. In this study, we have used reverse transcription polymerase chain reaction and Southern blot analysis to examine the presence of transcripts for the three CT antigens, NY-ESO-1, SSX2 and SCP1 in haematological malignant cells. We found that transcripts for SCP1 could be detected in 10% of myeloma, 5.7% of acute myeloid leukaemia and 23% of chronic myeloid leukaemia. In contrast, NY-ESO-1 and SSX2 were not detected in any of the 107 tumour samples. © 1999 Cancer Research Campaign Nature Publishing Group 1999-12 /pmc/articles/PMC2374325/ /pubmed/10584877 http://dx.doi.org/10.1038/sj.bjc.6690824 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Lim, S H
Austin, S
Owen-Jones, E
Robinson, L
Expression of testicular genes in haematological malignancies
title Expression of testicular genes in haematological malignancies
title_full Expression of testicular genes in haematological malignancies
title_fullStr Expression of testicular genes in haematological malignancies
title_full_unstemmed Expression of testicular genes in haematological malignancies
title_short Expression of testicular genes in haematological malignancies
title_sort expression of testicular genes in haematological malignancies
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374325/
https://www.ncbi.nlm.nih.gov/pubmed/10584877
http://dx.doi.org/10.1038/sj.bjc.6690824
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AT austins expressionoftesticulargenesinhaematologicalmalignancies
AT owenjonese expressionoftesticulargenesinhaematologicalmalignancies
AT robinsonl expressionoftesticulargenesinhaematologicalmalignancies

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