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Cytogenetic monoclonality in multifocal uroepithelial carcinomas: evidence of intraluminal tumour seeding

Twenty-one multifocal urinary tract transitional cell carcinomas, mostly bladder tumours, from a total of six patients were processed for cytogenetic analysis after short-term culturing of the tumour cells. Karyotypically related, often identical, cytogenetically complex clones were found in all inf...

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Autores principales: Fadl-Elmula, I, Gorunova, L, Mandahl, N, Elfving, P, Lundgren, R, Mitelman, F, Heim, S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374340/
https://www.ncbi.nlm.nih.gov/pubmed/10487605
http://dx.doi.org/10.1038/sj.bjc.6690643
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author Fadl-Elmula, I
Gorunova, L
Mandahl, N
Elfving, P
Lundgren, R
Mitelman, F
Heim, S
author_facet Fadl-Elmula, I
Gorunova, L
Mandahl, N
Elfving, P
Lundgren, R
Mitelman, F
Heim, S
author_sort Fadl-Elmula, I
collection PubMed
description Twenty-one multifocal urinary tract transitional cell carcinomas, mostly bladder tumours, from a total of six patients were processed for cytogenetic analysis after short-term culturing of the tumour cells. Karyotypically related, often identical, cytogenetically complex clones were found in all informative tumours from each case, including the recurrent tumours. Rearrangement of chromosome 9, leading to loss of material from the short and/or the long arm, was seen in all cases, indicating that this is an early, pathogenetically important event in transitional cell carcinogenesis. The presence of related clones with great karyotypic similarity in anatomically distinct tumours from the same bladder indicates that multifocal uroepithelial tumours have a monoclonal origin and arise via intraluminal seeding of viable cancer cells shed from the original tumour. Later lesions may develop also from cells shed from the so called second primary tumours. The relatively complex karyotypes seen in all lesions from most cases argue that the seeding of tumour cells is a late event that succeeds the acquisition by them of multiple secondary genetic abnormalities. © 1999 Cancer Research Campaign
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spelling pubmed-23743402009-09-10 Cytogenetic monoclonality in multifocal uroepithelial carcinomas: evidence of intraluminal tumour seeding Fadl-Elmula, I Gorunova, L Mandahl, N Elfving, P Lundgren, R Mitelman, F Heim, S Br J Cancer Regular Article Twenty-one multifocal urinary tract transitional cell carcinomas, mostly bladder tumours, from a total of six patients were processed for cytogenetic analysis after short-term culturing of the tumour cells. Karyotypically related, often identical, cytogenetically complex clones were found in all informative tumours from each case, including the recurrent tumours. Rearrangement of chromosome 9, leading to loss of material from the short and/or the long arm, was seen in all cases, indicating that this is an early, pathogenetically important event in transitional cell carcinogenesis. The presence of related clones with great karyotypic similarity in anatomically distinct tumours from the same bladder indicates that multifocal uroepithelial tumours have a monoclonal origin and arise via intraluminal seeding of viable cancer cells shed from the original tumour. Later lesions may develop also from cells shed from the so called second primary tumours. The relatively complex karyotypes seen in all lesions from most cases argue that the seeding of tumour cells is a late event that succeeds the acquisition by them of multiple secondary genetic abnormalities. © 1999 Cancer Research Campaign Nature Publishing Group 1999-09 /pmc/articles/PMC2374340/ /pubmed/10487605 http://dx.doi.org/10.1038/sj.bjc.6690643 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Fadl-Elmula, I
Gorunova, L
Mandahl, N
Elfving, P
Lundgren, R
Mitelman, F
Heim, S
Cytogenetic monoclonality in multifocal uroepithelial carcinomas: evidence of intraluminal tumour seeding
title Cytogenetic monoclonality in multifocal uroepithelial carcinomas: evidence of intraluminal tumour seeding
title_full Cytogenetic monoclonality in multifocal uroepithelial carcinomas: evidence of intraluminal tumour seeding
title_fullStr Cytogenetic monoclonality in multifocal uroepithelial carcinomas: evidence of intraluminal tumour seeding
title_full_unstemmed Cytogenetic monoclonality in multifocal uroepithelial carcinomas: evidence of intraluminal tumour seeding
title_short Cytogenetic monoclonality in multifocal uroepithelial carcinomas: evidence of intraluminal tumour seeding
title_sort cytogenetic monoclonality in multifocal uroepithelial carcinomas: evidence of intraluminal tumour seeding
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374340/
https://www.ncbi.nlm.nih.gov/pubmed/10487605
http://dx.doi.org/10.1038/sj.bjc.6690643
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