Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumourcells

The aim of the present study was to assess the cytotoxicity of manumycin, a specific inhibitor of farnesyl:protein transferase, as well as its effects on protein isoprenylation and kinase-dependent signal transduction in COLO320-DM human colon adenocarcinoma which harbours a wild-type K- ras gene. I...

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Detalles Bibliográficos
Autores principales: Paolo, A Di, Danesi, R, Nardini, D, Bocci, G, Innocenti, F, Fogli, S, Barachini, S, Marchetti, A, Bevilacqua, G, Tacca, M Del
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374379/
https://www.ncbi.nlm.nih.gov/pubmed/10732765
http://dx.doi.org/10.1054/bjoc.1999.1018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374379/
https://www.ncbi.nlm.nih.gov/pubmed/10732765
http://dx.doi.org/10.1054/bjoc.1999.1018

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