Cargando…

Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumourcells

The aim of the present study was to assess the cytotoxicity of manumycin, a specific inhibitor of farnesyl:protein transferase, as well as its effects on protein isoprenylation and kinase-dependent signal transduction in COLO320-DM human colon adenocarcinoma which harbours a wild-type K- ras gene. I...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paolo, A Di, Danesi, R, Nardini, D, Bocci, G, Innocenti, F, Fogli, S, Barachini, S, Marchetti, A, Bevilacqua, G, Tacca, M Del
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2000
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374379/ https://www.ncbi.nlm.nih.gov/pubmed/10732765 http://dx.doi.org/10.1054/bjoc.1999.1018

Ejemplares similares

In vitro targeting and selective killing of mcf-7 and colo320dm cells by 5-fluorouracil anchored to carboxylated SWCNTs and MWCNTs
por: Kamble, Rutuja V., et al.
Publicado: (2021)

Manumycin A corrects aberrant splicing of Clcn1 in myotonic dystrophy type 1 (DM1) mice
por: Oana, Kosuke, et al.
Publicado: (2013)

Green synthesis of silver and iron nanoparticles of isolated proanthocyanidin: its characterization, antioxidant, antimicrobial, and cytotoxic activities against COLO320DM and HT29
por: Shejawal, Kiran P., et al.
Publicado: (2020)

Green synthesis of silver, iron and gold nanoparticles of lycopene extracted from tomato: their characterization and cytotoxicity against COLO320DM, HT29 and Hella cell
por: Shejawal, Kiran P., et al.
Publicado: (2021)

Manumycin induces apoptosis in prostate cancer cells
por: Li, Jing-Gao, et al.
Publicado: (2014)

Analyzing the postulated inhibitory effect of Manumycin A on farnesyltransferase
por: Hagemann, Anna, et al.
Publicado: (2022)

Inhibition of protein farnesylation enhances the chemotherapeutic efficacy of the novel geranylgeranyltransferase inhibitor BAL9611 in human colon cancer cells
por: Paolo, A Di, et al.
Publicado: (2001)

107 Immunomodulatory Effects of Manumycin-type Antibiotics on Human Macrophages
por: Striz, Ilja, et al.
Publicado: (2012)

Interaction between gemcitabine and topotecan in human non-small-cell lung cancer cells: effects on cell survival, cell cycle and pharmacogenetic profile
por: Giovannetti, E, et al.
Publicado: (2005)

Manumycin and gliotoxin derivative KT7595 block Ras farnesylation and cell growth but do not disturb lamin farnesylation and localization in human tumour cells.
por: Nagase, T., et al.
Publicado: (1997)

Colo-Rectitis
por: Westmoreland, J. G.
Publicado: (1877)

Single-molecule fluorescence imaging of RalGDS on cell surfaces during signal transduction from Ras to Ral
por: Yoshizawa, Ryo, et al.
Publicado: (2017)

Manumycin Polyketides Act as Molecular Glues Between UBR7 and P53
por: Isobe, Yosuke, et al.
Publicado: (2020)

Continuous angiotensin II infusion increases tumour: normal blood flow ratio in colo-rectal liver metastases
por: Burke, D, et al.
Publicado: (2001)

Polyporenic Acids from the Mushroom Buglossoporus quercinus Possess Chemosensitizing and Efflux Pump Inhibitory Activities on Colo 320 Adenocarcinoma Cells
por: Felegyi, Kristóf, et al.
Publicado: (2023)

On Colo-Puncture
por: Cameron, Hector C.
Publicado: (1873)

Reduced tumour growth of the human colonic cancer cell lines COLO-320 and HT-29 in vivo by dietary n-3 lipids.
por: Sakaguchi, M., et al.
Publicado: (1990)

Inhibition of the Heat Shock Protein A (HSPA) Family Potentiates the Anticancer Effects of Manumycin A
por: Sojka, Damian Robert, et al.
Publicado: (2021)

Phenotypic characteristics of colo-rectal cancer in I1307K APC germline mutation carriers compared with sporadic cases
por: Figer, A, et al.
Publicado: (2001)

Colo-ovarian fistula
por: Rosenzweig, Matthew, et al.
Publicado: (2017)

Colo tuituit : tres cuentos infantiles
por: Palacios, Adela
Publicado: (1969)

siRNA directed against c-Myc inhibits proliferation and downregulates human telomerase reverse transcriptase in human colon cancer Colo 320 cells
por: Hao, Huang, et al.
Publicado: (2008)

Retraction: siRNA directed against c-Myc inhibits proliferation and downregulates human telomerase reverse transcriptase in human colon cancer Colo 320 cells
por: Hao, Huang, et al.
Publicado: (2009)

A Game of ColoMonopoly
por: Nakshabendi, Rahman, et al.
Publicado: (2016)

Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells
por: Bocci, G, et al.
Publicado: (2005)

Enhanced Antiproliferative and Apoptotic Response of HT-29 Adenocarcinoma Cells to Combination of Photoactivated Hypericin and Farnesyltransferase Inhibitor Manumycin A
por: Sačková, Veronika, et al.
Publicado: (2011)

Manumycin A inhibits triple-negative breast cancer growth through LC3-mediated cytoplasmic vacuolation death
por: Singha, P K, et al.
Publicado: (2013)

Suppression of Human Pancreatic Cancer Growth in BALB/c Nude Mice by Manumycin, a Farnesyl:protein Transferase Inhibitor
por: Ito, Toshio, et al.
Publicado: (1996)

Activation of a Cryptic Manumycin-Type Biosynthetic Gene Cluster of Saccharothrix espanaensis DSM44229 by Series of Genetic Manipulations
por: Gorniaková, Dominika, et al.
Publicado: (2021)

Variation in response of xenografts of colo-rectal carcinoma to chemotherapy.
por: Nowak, K., et al.
Publicado: (1978)

Spontaneous colo-vesical and colo-cutaneous fistula complicating a sigmoid diverticulitis: A case report
por: Faye, Papa Mamadou, et al.
Publicado: (2021)

Review of Gastric and Colo-rectal Cancers
por: Bush, H.
Publicado: (1978)

Laparoscopic colo-rectal surgery in octogenarians
por: Martina, Coletta, et al.
Publicado: (2009)

A Curious Colo-Uterine Anomaly
Publicado: (1930)

Circulating Tumor DNA: The Dawn of a New Era in the Optimization of Chemotherapeutic Strategies for Metastatic Colo-Rectal Cancer Focusing on RAS Mutation
por: Udagawa, Shohei, et al.
Publicado: (2023)

Pharmacogenetics of anticancer drugs in non-Hodgkin lymphomas
por: Loni, L, et al.
Publicado: (2001)

Antitumor effect of manumycin on colorectal cancer cells by increasing the reactive oxygen species production and blocking PI3K-AKT pathway
por: Zhang, Jingyu, et al.
Publicado: (2016)

Automated MRI volumetry as a diagnostic tool for Alzheimer's disease: Validation of icobrain dm
por: Struyfs, Hanne, et al.
Publicado: (2020)

Early Postendoscopic Transverse Colo-Colonic Intussusception
por: He, Harry, et al.
Publicado: (2020)

A Rare Case of Diverticulitis With a Colo-Adnexal Fistula
por: Gopalan, Varsha, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_oi6b55p9u3eb29uem6ljuipd1q