Cargando…

Role and new perspectives of transforming growth factor-α (TGF- α) in adenocarcinoma of the gastro-oesophageal junction

The incidence of gastro-oesophageal junction (GEJ) adenocarcinoma is increasing in Western countries and prognosis is poor since metastasis is most often present at diagnosis. We examined samples from 87 resected type II GEJ adenocarcinomas, 30 of these with endoscopic diagnostic biopsy material, to...

Descripción completa

Detalles Bibliográficos
Autores principales: D'Errico, A, Barozzi, C, Fiorentino, M, Carella, R, Simone, M Di, Ferruzzi, L, Mattioli, S, Grigioni, W F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374390/
https://www.ncbi.nlm.nih.gov/pubmed/10732760
http://dx.doi.org/10.1054/bjoc.1999.1013
_version_ 1782154442199531520
author D'Errico, A
Barozzi, C
Fiorentino, M
Carella, R
Simone, M Di
Ferruzzi, L
Mattioli, S
Grigioni, W F
author_facet D'Errico, A
Barozzi, C
Fiorentino, M
Carella, R
Simone, M Di
Ferruzzi, L
Mattioli, S
Grigioni, W F
author_sort D'Errico, A
collection PubMed
description The incidence of gastro-oesophageal junction (GEJ) adenocarcinoma is increasing in Western countries and prognosis is poor since metastasis is most often present at diagnosis. We examined samples from 87 resected type II GEJ adenocarcinomas, 30 of these with endoscopic diagnostic biopsy material, to evaluate transforming growth factor alpha (TGF-α) expression and p53 overexpression by immunohistochemistry and in situ hybridization (for TGF-α), in relation to biological and clinical behaviour. TGF-α messenger RNA (mRNA) and protein were detectable in neoplastic cells in 56% and 64% cases respectively. TGF-α mRNA was detected in intra- and peritumoral lymphocytes and those of metastatic lymph nodes. TGF-α protein expression was significantly associated with tumour progression (P = 0.025) and lymph node metastasis (P< 0.05). The strong TGF-α expression found in neoplastic cells inside blood and lymphatic vessels and in metastatic localizations suggests that TGF-α-positive GEJ adenocarcinomas could have a more aggressive biological phenotype. The expression of TGF-α mRNA and protein in both inflammatory and neoplastic cells indicates that TGF-α is directly synthesized by both cell compartments. Finally, since TGF-α expression was associated with lymph node metastasis, its detection in preoperative perendoscopic biopsies might identify patients with more aggressive tumours who may need additional therapy, including neo-adjuvant treatment. © 2000 Cancer Research Campaign
format Text
id pubmed-2374390
institution National Center for Biotechnology Information
language English
publishDate 2000
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23743902009-09-10 Role and new perspectives of transforming growth factor-α (TGF- α) in adenocarcinoma of the gastro-oesophageal junction D'Errico, A Barozzi, C Fiorentino, M Carella, R Simone, M Di Ferruzzi, L Mattioli, S Grigioni, W F Br J Cancer Regular Article The incidence of gastro-oesophageal junction (GEJ) adenocarcinoma is increasing in Western countries and prognosis is poor since metastasis is most often present at diagnosis. We examined samples from 87 resected type II GEJ adenocarcinomas, 30 of these with endoscopic diagnostic biopsy material, to evaluate transforming growth factor alpha (TGF-α) expression and p53 overexpression by immunohistochemistry and in situ hybridization (for TGF-α), in relation to biological and clinical behaviour. TGF-α messenger RNA (mRNA) and protein were detectable in neoplastic cells in 56% and 64% cases respectively. TGF-α mRNA was detected in intra- and peritumoral lymphocytes and those of metastatic lymph nodes. TGF-α protein expression was significantly associated with tumour progression (P = 0.025) and lymph node metastasis (P< 0.05). The strong TGF-α expression found in neoplastic cells inside blood and lymphatic vessels and in metastatic localizations suggests that TGF-α-positive GEJ adenocarcinomas could have a more aggressive biological phenotype. The expression of TGF-α mRNA and protein in both inflammatory and neoplastic cells indicates that TGF-α is directly synthesized by both cell compartments. Finally, since TGF-α expression was associated with lymph node metastasis, its detection in preoperative perendoscopic biopsies might identify patients with more aggressive tumours who may need additional therapy, including neo-adjuvant treatment. © 2000 Cancer Research Campaign Nature Publishing Group 2000-02 /pmc/articles/PMC2374390/ /pubmed/10732760 http://dx.doi.org/10.1054/bjoc.1999.1013 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
D'Errico, A
Barozzi, C
Fiorentino, M
Carella, R
Simone, M Di
Ferruzzi, L
Mattioli, S
Grigioni, W F
Role and new perspectives of transforming growth factor-α (TGF- α) in adenocarcinoma of the gastro-oesophageal junction
title Role and new perspectives of transforming growth factor-α (TGF- α) in adenocarcinoma of the gastro-oesophageal junction
title_full Role and new perspectives of transforming growth factor-α (TGF- α) in adenocarcinoma of the gastro-oesophageal junction
title_fullStr Role and new perspectives of transforming growth factor-α (TGF- α) in adenocarcinoma of the gastro-oesophageal junction
title_full_unstemmed Role and new perspectives of transforming growth factor-α (TGF- α) in adenocarcinoma of the gastro-oesophageal junction
title_short Role and new perspectives of transforming growth factor-α (TGF- α) in adenocarcinoma of the gastro-oesophageal junction
title_sort role and new perspectives of transforming growth factor-α (tgf- α) in adenocarcinoma of the gastro-oesophageal junction
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374390/
https://www.ncbi.nlm.nih.gov/pubmed/10732760
http://dx.doi.org/10.1054/bjoc.1999.1013
work_keys_str_mv AT derricoa roleandnewperspectivesoftransforminggrowthfactoratgfainadenocarcinomaofthegastrooesophagealjunction
AT barozzic roleandnewperspectivesoftransforminggrowthfactoratgfainadenocarcinomaofthegastrooesophagealjunction
AT fiorentinom roleandnewperspectivesoftransforminggrowthfactoratgfainadenocarcinomaofthegastrooesophagealjunction
AT carellar roleandnewperspectivesoftransforminggrowthfactoratgfainadenocarcinomaofthegastrooesophagealjunction
AT simonemdi roleandnewperspectivesoftransforminggrowthfactoratgfainadenocarcinomaofthegastrooesophagealjunction
AT ferruzzil roleandnewperspectivesoftransforminggrowthfactoratgfainadenocarcinomaofthegastrooesophagealjunction
AT mattiolis roleandnewperspectivesoftransforminggrowthfactoratgfainadenocarcinomaofthegastrooesophagealjunction
AT grigioniwf roleandnewperspectivesoftransforminggrowthfactoratgfainadenocarcinomaofthegastrooesophagealjunction