No association betweenP53codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck

An initial report suggested that patients homozygous for the arginine allele at codon 72 ofP53were at increased risk for human papillomavirus (HPV)-related cervical cancer, but other groups have not confirmed this finding. Since approximately 18–36% of head and neck cancers are HPV-related, we exami...

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Autores principales: Hamel, N, Black, M J, Ghadirian, P, Foulkes, W D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374404/
https://www.ncbi.nlm.nih.gov/pubmed/10732740
http://dx.doi.org/10.1054/bjoc.1999.0993
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author Hamel, N
Black, M J
Ghadirian, P
Foulkes, W D
author_facet Hamel, N
Black, M J
Ghadirian, P
Foulkes, W D
author_sort Hamel, N
collection PubMed
description An initial report suggested that patients homozygous for the arginine allele at codon 72 ofP53were at increased risk for human papillomavirus (HPV)-related cervical cancer, but other groups have not confirmed this finding. Since approximately 18–36% of head and neck cancers are HPV-related, we examined the genotypic frequencies at that locus in 163 cases with squamous cell carcinoma of the head and neck (SCCHN) and 163 ethnically matched controls. We found no significant excess of arginine homozygotes in cases compared to controls (P= 0.50). No significant differences in allele frequencies were observed when the data were stratified by tobacco exposure or by cancer site. These findings suggest a limited role, if any, for thisP53polymorphism in SCCHN.© 2000 Cancer Research Campaign
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spelling pubmed-23744042009-09-10 No association betweenP53codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck Hamel, N Black, M J Ghadirian, P Foulkes, W D Br J Cancer Short Communication An initial report suggested that patients homozygous for the arginine allele at codon 72 ofP53were at increased risk for human papillomavirus (HPV)-related cervical cancer, but other groups have not confirmed this finding. Since approximately 18–36% of head and neck cancers are HPV-related, we examined the genotypic frequencies at that locus in 163 cases with squamous cell carcinoma of the head and neck (SCCHN) and 163 ethnically matched controls. We found no significant excess of arginine homozygotes in cases compared to controls (P= 0.50). No significant differences in allele frequencies were observed when the data were stratified by tobacco exposure or by cancer site. These findings suggest a limited role, if any, for thisP53polymorphism in SCCHN.© 2000 Cancer Research Campaign Nature Publishing Group 2000-02 /pmc/articles/PMC2374404/ /pubmed/10732740 http://dx.doi.org/10.1054/bjoc.1999.0993 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Hamel, N
Black, M J
Ghadirian, P
Foulkes, W D
No association betweenP53codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck
title No association betweenP53codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck
title_full No association betweenP53codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck
title_fullStr No association betweenP53codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck
title_full_unstemmed No association betweenP53codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck
title_short No association betweenP53codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck
title_sort no association betweenp53codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374404/
https://www.ncbi.nlm.nih.gov/pubmed/10732740
http://dx.doi.org/10.1054/bjoc.1999.0993
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