Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-α was added to t...

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Autores principales: de Wilt, J H W, ten Hagen, T L M, de Boeck, G, van Tiel, S T, de Bruijn, E A, Eggermont, A M M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374420/
https://www.ncbi.nlm.nih.gov/pubmed/10737379
http://dx.doi.org/10.1054/bjoc.1999.1032
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author de Wilt, J H W
ten Hagen, T L M
de Boeck, G
van Tiel, S T
de Bruijn, E A
Eggermont, A M M
author_facet de Wilt, J H W
ten Hagen, T L M
de Boeck, G
van Tiel, S T
de Bruijn, E A
Eggermont, A M M
author_sort de Wilt, J H W
collection PubMed
description Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-α was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-α in ILP. © 2000 Cancer Research Campaign
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spelling pubmed-23744202009-09-10 Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion de Wilt, J H W ten Hagen, T L M de Boeck, G van Tiel, S T de Bruijn, E A Eggermont, A M M Br J Cancer Short Communication Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-α was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-α in ILP. © 2000 Cancer Research Campaign Nature Publishing Group 2000-03 2000-02-01 /pmc/articles/PMC2374420/ /pubmed/10737379 http://dx.doi.org/10.1054/bjoc.1999.1032 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
de Wilt, J H W
ten Hagen, T L M
de Boeck, G
van Tiel, S T
de Bruijn, E A
Eggermont, A M M
Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion
title Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion
title_full Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion
title_fullStr Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion
title_full_unstemmed Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion
title_short Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion
title_sort tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374420/
https://www.ncbi.nlm.nih.gov/pubmed/10737379
http://dx.doi.org/10.1054/bjoc.1999.1032
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