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Risk factors for nephrotoxicity after ifosfamide treatment in children: a UKCCSG Late Effects Group study
The aim of this multicentre study was to document the nephrotoxicity associated with ifosfamide and evaluate risk factors in 148 children and young people with sarcomas who underwent investigation of renal function on one occasion each, at a median of 6 (range 1–47) months after completion of ifosfa...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2000
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374517/ https://www.ncbi.nlm.nih.gov/pubmed/10817497 http://dx.doi.org/10.1054/bjoc.2000.1214 |
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author | Skinner, R Cotterill, S J Stevens, M C G |
author_facet | Skinner, R Cotterill, S J Stevens, M C G |
author_sort | Skinner, R |
collection | PubMed |
description | The aim of this multicentre study was to document the nephrotoxicity associated with ifosfamide and evaluate risk factors in 148 children and young people with sarcomas who underwent investigation of renal function on one occasion each, at a median of 6 (range 1–47) months after completion of ifosfamide (median dose 62.0 (range 6.1–165.0) g/m(2)). Investigations included glomerular filtration rate (GFR), serum bicarbonate (HCO(3)) and phosphate (PO(4)), and renal tubular threshold for phosphate (Tm(p)/GFR). A clinically relevant ‘nephrotoxicity score’ was derived. GFR was < 90 ml/min/1.73 m(2)in 61 of 123 evaluable patients, Tm(p)/GFR < 0.9–1.1 mmol/l (age-dependent) in 45/103, serum PO(4)< 0.9–1.mmol/l (age-dependent) in 28/135, and serum HCO(3)< 20 (< 18 in infants) mmol/l in 22/95. Of 76 fully evaluable patients: 50% had mild, 20% moderate and 8% severe nephrotoxicity. Higher total ifosfamide dose correlated significantly with greater glomerular and tubular toxicity (P< 0.01); other risk factors, including age at treatment, demonstrated no consistent significant independent effect. Chronic ifosfamide-related glomerular and proximal tubular toxicity were common in this large comprehensive study. Restriction of total ifosfamide dose to < 84 g/m(2)will reduce the frequency of, but not abolish, clinically significant nephrotoxicity, whilst doses > 119 g/m(2)are associated with a very high risk of severe toxicity. © 2000 Cancer Research Campaign |
format | Text |
id | pubmed-2374517 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23745172009-09-10 Risk factors for nephrotoxicity after ifosfamide treatment in children: a UKCCSG Late Effects Group study Skinner, R Cotterill, S J Stevens, M C G Br J Cancer Regular Article The aim of this multicentre study was to document the nephrotoxicity associated with ifosfamide and evaluate risk factors in 148 children and young people with sarcomas who underwent investigation of renal function on one occasion each, at a median of 6 (range 1–47) months after completion of ifosfamide (median dose 62.0 (range 6.1–165.0) g/m(2)). Investigations included glomerular filtration rate (GFR), serum bicarbonate (HCO(3)) and phosphate (PO(4)), and renal tubular threshold for phosphate (Tm(p)/GFR). A clinically relevant ‘nephrotoxicity score’ was derived. GFR was < 90 ml/min/1.73 m(2)in 61 of 123 evaluable patients, Tm(p)/GFR < 0.9–1.1 mmol/l (age-dependent) in 45/103, serum PO(4)< 0.9–1.mmol/l (age-dependent) in 28/135, and serum HCO(3)< 20 (< 18 in infants) mmol/l in 22/95. Of 76 fully evaluable patients: 50% had mild, 20% moderate and 8% severe nephrotoxicity. Higher total ifosfamide dose correlated significantly with greater glomerular and tubular toxicity (P< 0.01); other risk factors, including age at treatment, demonstrated no consistent significant independent effect. Chronic ifosfamide-related glomerular and proximal tubular toxicity were common in this large comprehensive study. Restriction of total ifosfamide dose to < 84 g/m(2)will reduce the frequency of, but not abolish, clinically significant nephrotoxicity, whilst doses > 119 g/m(2)are associated with a very high risk of severe toxicity. © 2000 Cancer Research Campaign Nature Publishing Group 2000-05 2000-04-27 /pmc/articles/PMC2374517/ /pubmed/10817497 http://dx.doi.org/10.1054/bjoc.2000.1214 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Regular Article Skinner, R Cotterill, S J Stevens, M C G Risk factors for nephrotoxicity after ifosfamide treatment in children: a UKCCSG Late Effects Group study |
title | Risk factors for nephrotoxicity after ifosfamide treatment in children: a UKCCSG Late Effects Group study |
title_full | Risk factors for nephrotoxicity after ifosfamide treatment in children: a UKCCSG Late Effects Group study |
title_fullStr | Risk factors for nephrotoxicity after ifosfamide treatment in children: a UKCCSG Late Effects Group study |
title_full_unstemmed | Risk factors for nephrotoxicity after ifosfamide treatment in children: a UKCCSG Late Effects Group study |
title_short | Risk factors for nephrotoxicity after ifosfamide treatment in children: a UKCCSG Late Effects Group study |
title_sort | risk factors for nephrotoxicity after ifosfamide treatment in children: a ukccsg late effects group study |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374517/ https://www.ncbi.nlm.nih.gov/pubmed/10817497 http://dx.doi.org/10.1054/bjoc.2000.1214 |
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