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Aberrant expression of cyclin A in head and neck cancer
Cyclin A expression was studied in a series of 65 squamous cell carcinomas of the head and neck (HNSCC) and compared with known markers of proliferation, iododeoxyuridine (IdUrd) and Ki-67, to assess whether aberrant expression was prevalent. Patients had previously been administered IdUrd to study...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2000
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374545/ https://www.ncbi.nlm.nih.gov/pubmed/10883664 http://dx.doi.org/10.1054/bjoc.2000.1193 |
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author | Lotayef, M Wilson, G D Daley, F M Awwad, H K Shouman, T |
author_facet | Lotayef, M Wilson, G D Daley, F M Awwad, H K Shouman, T |
author_sort | Lotayef, M |
collection | PubMed |
description | Cyclin A expression was studied in a series of 65 squamous cell carcinomas of the head and neck (HNSCC) and compared with known markers of proliferation, iododeoxyuridine (IdUrd) and Ki-67, to assess whether aberrant expression was prevalent. Patients had previously been administered IdUrd to study cell kinetics in relation to outcome of radiotherapy. The data showed that all three parameters were highly correlated although the absolute values were different. The median labelling indices (LI) for IdUrd, cyclin A and Ki-67 were 10.7, 17.1 and 30.8% respectively, reflecting the known pattern of differential cell cycle expression. However, there were a significant number of cases in which an unexpected relationship between cyclin A and either IdUrd or Ki-67 was present. Some of these were attributable to overexpression but others indicated underexpression. Although the greater variability and range of cyclin A expression, coupled with its more closely associated role in cell cycle regulation, might suggest that it may be a more informative marker for cell proliferation than Ki-67, the aberrant expression seen in over one third of cases would indicate that caution should be exercised in interpreting cyclin A as a surrogate marker of proliferation in HNSCC. © 2000 Cancer Research Campaign |
format | Text |
id | pubmed-2374545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23745452009-09-10 Aberrant expression of cyclin A in head and neck cancer Lotayef, M Wilson, G D Daley, F M Awwad, H K Shouman, T Br J Cancer Regular Article Cyclin A expression was studied in a series of 65 squamous cell carcinomas of the head and neck (HNSCC) and compared with known markers of proliferation, iododeoxyuridine (IdUrd) and Ki-67, to assess whether aberrant expression was prevalent. Patients had previously been administered IdUrd to study cell kinetics in relation to outcome of radiotherapy. The data showed that all three parameters were highly correlated although the absolute values were different. The median labelling indices (LI) for IdUrd, cyclin A and Ki-67 were 10.7, 17.1 and 30.8% respectively, reflecting the known pattern of differential cell cycle expression. However, there were a significant number of cases in which an unexpected relationship between cyclin A and either IdUrd or Ki-67 was present. Some of these were attributable to overexpression but others indicated underexpression. Although the greater variability and range of cyclin A expression, coupled with its more closely associated role in cell cycle regulation, might suggest that it may be a more informative marker for cell proliferation than Ki-67, the aberrant expression seen in over one third of cases would indicate that caution should be exercised in interpreting cyclin A as a surrogate marker of proliferation in HNSCC. © 2000 Cancer Research Campaign Nature Publishing Group 2000-07 2000-06-02 /pmc/articles/PMC2374545/ /pubmed/10883664 http://dx.doi.org/10.1054/bjoc.2000.1193 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Regular Article Lotayef, M Wilson, G D Daley, F M Awwad, H K Shouman, T Aberrant expression of cyclin A in head and neck cancer |
title | Aberrant expression of cyclin A in head and neck cancer |
title_full | Aberrant expression of cyclin A in head and neck cancer |
title_fullStr | Aberrant expression of cyclin A in head and neck cancer |
title_full_unstemmed | Aberrant expression of cyclin A in head and neck cancer |
title_short | Aberrant expression of cyclin A in head and neck cancer |
title_sort | aberrant expression of cyclin a in head and neck cancer |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374545/ https://www.ncbi.nlm.nih.gov/pubmed/10883664 http://dx.doi.org/10.1054/bjoc.2000.1193 |
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