Contralateral breast cancer risk is influenced by the age at onset in BRCA1-associated breast cancer

BRCA1/2 mutation carriers diagnosed with breast cancer have a strongly elevated life-time risk of developing a contralateral tumour. We studied the contralateral breast cancer risk in 164 patients from 83 families with a proven BRCA1 mutation in relation to the age at diagnosis of the first primary...

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Autores principales: Verhoog, L C, Brekelmans, C T M, Seynaeve, C, Meijers-Heijboer, E J, Klijn, J G M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374577/
https://www.ncbi.nlm.nih.gov/pubmed/10917555
http://dx.doi.org/10.1054/bjoc.2000.1239
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author Verhoog, L C
Brekelmans, C T M
Seynaeve, C
Meijers-Heijboer, E J
Klijn, J G M
author_facet Verhoog, L C
Brekelmans, C T M
Seynaeve, C
Meijers-Heijboer, E J
Klijn, J G M
author_sort Verhoog, L C
collection PubMed
description BRCA1/2 mutation carriers diagnosed with breast cancer have a strongly elevated life-time risk of developing a contralateral tumour. We studied the contralateral breast cancer risk in 164 patients from 83 families with a proven BRCA1 mutation in relation to the age at diagnosis of the first primary breast cancer. In the actuarial outcomes after 10 years’ follow-up, 40% of the 124 BRCA1-patients diagnosed with breast cancer < 50 years had developed contralateral breast cancer, vs 12% of the 40 patients > 50 years at first diagnosis (P(logrank)= 0.02). These data suggest that age at diagnosis of the first tumour should be taken into account when prophylactic mastectomy in BRCA1-patients is considered. © 2000 Cancer Research Campaign
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spelling pubmed-23745772009-09-10 Contralateral breast cancer risk is influenced by the age at onset in BRCA1-associated breast cancer Verhoog, L C Brekelmans, C T M Seynaeve, C Meijers-Heijboer, E J Klijn, J G M Br J Cancer Regular Article BRCA1/2 mutation carriers diagnosed with breast cancer have a strongly elevated life-time risk of developing a contralateral tumour. We studied the contralateral breast cancer risk in 164 patients from 83 families with a proven BRCA1 mutation in relation to the age at diagnosis of the first primary breast cancer. In the actuarial outcomes after 10 years’ follow-up, 40% of the 124 BRCA1-patients diagnosed with breast cancer < 50 years had developed contralateral breast cancer, vs 12% of the 40 patients > 50 years at first diagnosis (P(logrank)= 0.02). These data suggest that age at diagnosis of the first tumour should be taken into account when prophylactic mastectomy in BRCA1-patients is considered. © 2000 Cancer Research Campaign Nature Publishing Group 2000-07 2000-07-03 /pmc/articles/PMC2374577/ /pubmed/10917555 http://dx.doi.org/10.1054/bjoc.2000.1239 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Verhoog, L C
Brekelmans, C T M
Seynaeve, C
Meijers-Heijboer, E J
Klijn, J G M
Contralateral breast cancer risk is influenced by the age at onset in BRCA1-associated breast cancer
title Contralateral breast cancer risk is influenced by the age at onset in BRCA1-associated breast cancer
title_full Contralateral breast cancer risk is influenced by the age at onset in BRCA1-associated breast cancer
title_fullStr Contralateral breast cancer risk is influenced by the age at onset in BRCA1-associated breast cancer
title_full_unstemmed Contralateral breast cancer risk is influenced by the age at onset in BRCA1-associated breast cancer
title_short Contralateral breast cancer risk is influenced by the age at onset in BRCA1-associated breast cancer
title_sort contralateral breast cancer risk is influenced by the age at onset in brca1-associated breast cancer
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374577/
https://www.ncbi.nlm.nih.gov/pubmed/10917555
http://dx.doi.org/10.1054/bjoc.2000.1239
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