Genomic alterations associated with loss of heterozygosity for TP53 in Li-Fraumeni syndrome fibroblasts

Studies of Li-Fraumeni syndrome fibroblasts heterozygous for germline TP53 mutations have shown that loss of heterozygosity (LOH) occurs during passaging and is associated with genomic instability, such as chromosomal aberrations and aneuploidy. to investigate the genomic changes associated with LOH...

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Detalles Bibliográficos
Autores principales: Burt, E C, James, L A, Greaves, M J, Birch, J M, Boyle, J M, Varley, J M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374657/
https://www.ncbi.nlm.nih.gov/pubmed/10945493
http://dx.doi.org/10.1054/bjoc.2000.1292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374657/
https://www.ncbi.nlm.nih.gov/pubmed/10945493
http://dx.doi.org/10.1054/bjoc.2000.1292

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