Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer

Loss of hormone receptor (HR) status in breast carcinomas is associated with increased tumour cell motility and invasiveness. In an immunohistological study of 58 primary breast cancers, oestrogen (ER) and progesterone (PR) receptor levels were inversely correlated with the expression of fascin, an...

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Autores principales: Grothey, A, Hashizume, R, Sahin, A A, McCrea, P D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374674/
https://www.ncbi.nlm.nih.gov/pubmed/10970687
http://dx.doi.org/10.1054/bjoc.2000.1395
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author Grothey, A
Hashizume, R
Sahin, A A
McCrea, P D
author_facet Grothey, A
Hashizume, R
Sahin, A A
McCrea, P D
author_sort Grothey, A
collection PubMed
description Loss of hormone receptor (HR) status in breast carcinomas is associated with increased tumour cell motility and invasiveness. In an immunohistological study of 58 primary breast cancers, oestrogen (ER) and progesterone (PR) receptor levels were inversely correlated with the expression of fascin, an actin-bundling protein associated with cell motility (P< 0.0001 and P = 0.0019, respectively). In addition, fascin was preferentially expressed in non-diploid tumours (P = 0.03). In summary, the upregulation of fascin in HR-negative breast cancers may contribute to their more aggressive behaviour. © 2000 Cancer Research Campaign
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spelling pubmed-23746742009-09-10 Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer Grothey, A Hashizume, R Sahin, A A McCrea, P D Br J Cancer Short Communication Loss of hormone receptor (HR) status in breast carcinomas is associated with increased tumour cell motility and invasiveness. In an immunohistological study of 58 primary breast cancers, oestrogen (ER) and progesterone (PR) receptor levels were inversely correlated with the expression of fascin, an actin-bundling protein associated with cell motility (P< 0.0001 and P = 0.0019, respectively). In addition, fascin was preferentially expressed in non-diploid tumours (P = 0.03). In summary, the upregulation of fascin in HR-negative breast cancers may contribute to their more aggressive behaviour. © 2000 Cancer Research Campaign Nature Publishing Group 2000-10 2000-09-04 /pmc/articles/PMC2374674/ /pubmed/10970687 http://dx.doi.org/10.1054/bjoc.2000.1395 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Grothey, A
Hashizume, R
Sahin, A A
McCrea, P D
Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer
title Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer
title_full Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer
title_fullStr Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer
title_full_unstemmed Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer
title_short Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer
title_sort fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374674/
https://www.ncbi.nlm.nih.gov/pubmed/10970687
http://dx.doi.org/10.1054/bjoc.2000.1395
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