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Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer
Loss of hormone receptor (HR) status in breast carcinomas is associated with increased tumour cell motility and invasiveness. In an immunohistological study of 58 primary breast cancers, oestrogen (ER) and progesterone (PR) receptor levels were inversely correlated with the expression of fascin, an...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2000
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374674/ https://www.ncbi.nlm.nih.gov/pubmed/10970687 http://dx.doi.org/10.1054/bjoc.2000.1395 |
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author | Grothey, A Hashizume, R Sahin, A A McCrea, P D |
author_facet | Grothey, A Hashizume, R Sahin, A A McCrea, P D |
author_sort | Grothey, A |
collection | PubMed |
description | Loss of hormone receptor (HR) status in breast carcinomas is associated with increased tumour cell motility and invasiveness. In an immunohistological study of 58 primary breast cancers, oestrogen (ER) and progesterone (PR) receptor levels were inversely correlated with the expression of fascin, an actin-bundling protein associated with cell motility (P< 0.0001 and P = 0.0019, respectively). In addition, fascin was preferentially expressed in non-diploid tumours (P = 0.03). In summary, the upregulation of fascin in HR-negative breast cancers may contribute to their more aggressive behaviour. © 2000 Cancer Research Campaign |
format | Text |
id | pubmed-2374674 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23746742009-09-10 Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer Grothey, A Hashizume, R Sahin, A A McCrea, P D Br J Cancer Short Communication Loss of hormone receptor (HR) status in breast carcinomas is associated with increased tumour cell motility and invasiveness. In an immunohistological study of 58 primary breast cancers, oestrogen (ER) and progesterone (PR) receptor levels were inversely correlated with the expression of fascin, an actin-bundling protein associated with cell motility (P< 0.0001 and P = 0.0019, respectively). In addition, fascin was preferentially expressed in non-diploid tumours (P = 0.03). In summary, the upregulation of fascin in HR-negative breast cancers may contribute to their more aggressive behaviour. © 2000 Cancer Research Campaign Nature Publishing Group 2000-10 2000-09-04 /pmc/articles/PMC2374674/ /pubmed/10970687 http://dx.doi.org/10.1054/bjoc.2000.1395 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Short Communication Grothey, A Hashizume, R Sahin, A A McCrea, P D Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer |
title | Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer |
title_full | Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer |
title_fullStr | Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer |
title_full_unstemmed | Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer |
title_short | Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer |
title_sort | fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374674/ https://www.ncbi.nlm.nih.gov/pubmed/10970687 http://dx.doi.org/10.1054/bjoc.2000.1395 |
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