Haemophilus influenzae type B vaccination and risk of childhood leukaemia in a vaccine trial in Finland

Incidence of childhood leukaemia was studied among subjects of a trial comparing administration of several doses of a conjugate vaccine against Haemophilus influenzae type b (Hib) starting at an early age (three months) with a single dose given at the age of two years. Among 114 000 subjects, a tota...

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Autores principales: Auvinen, A, Hakulinen, T, Groves, F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374693/
https://www.ncbi.nlm.nih.gov/pubmed/10970701
http://dx.doi.org/10.1054/bjoc.2000.1382
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author Auvinen, A
Hakulinen, T
Groves, F
author_facet Auvinen, A
Hakulinen, T
Groves, F
author_sort Auvinen, A
collection PubMed
description Incidence of childhood leukaemia was studied among subjects of a trial comparing administration of several doses of a conjugate vaccine against Haemophilus influenzae type b (Hib) starting at an early age (three months) with a single dose given at the age of two years. Among 114 000 subjects, a total of 77 cases of childhood leukaemia were detected. The incidence of childhood leukaemia was lower in the early vaccination arm (relative risk 0.72, 95% confidence interval 0.46–1.13) than late vaccination arm, but the difference did not reach statistical significance. Our results suggest that early immunization against Hib may reduce the incidence of childhood leukaemia, but confirmatory studies are needed. © 2000 Cancer Research Campaign
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spelling pubmed-23746932009-09-10 Haemophilus influenzae type B vaccination and risk of childhood leukaemia in a vaccine trial in Finland Auvinen, A Hakulinen, T Groves, F Br J Cancer Regular Article Incidence of childhood leukaemia was studied among subjects of a trial comparing administration of several doses of a conjugate vaccine against Haemophilus influenzae type b (Hib) starting at an early age (three months) with a single dose given at the age of two years. Among 114 000 subjects, a total of 77 cases of childhood leukaemia were detected. The incidence of childhood leukaemia was lower in the early vaccination arm (relative risk 0.72, 95% confidence interval 0.46–1.13) than late vaccination arm, but the difference did not reach statistical significance. Our results suggest that early immunization against Hib may reduce the incidence of childhood leukaemia, but confirmatory studies are needed. © 2000 Cancer Research Campaign Nature Publishing Group 2000-10 2000-09-04 /pmc/articles/PMC2374693/ /pubmed/10970701 http://dx.doi.org/10.1054/bjoc.2000.1382 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Auvinen, A
Hakulinen, T
Groves, F
Haemophilus influenzae type B vaccination and risk of childhood leukaemia in a vaccine trial in Finland
title Haemophilus influenzae type B vaccination and risk of childhood leukaemia in a vaccine trial in Finland
title_full Haemophilus influenzae type B vaccination and risk of childhood leukaemia in a vaccine trial in Finland
title_fullStr Haemophilus influenzae type B vaccination and risk of childhood leukaemia in a vaccine trial in Finland
title_full_unstemmed Haemophilus influenzae type B vaccination and risk of childhood leukaemia in a vaccine trial in Finland
title_short Haemophilus influenzae type B vaccination and risk of childhood leukaemia in a vaccine trial in Finland
title_sort haemophilus influenzae type b vaccination and risk of childhood leukaemia in a vaccine trial in finland
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374693/
https://www.ncbi.nlm.nih.gov/pubmed/10970701
http://dx.doi.org/10.1054/bjoc.2000.1382
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AT hakulinent haemophilusinfluenzaetypebvaccinationandriskofchildhoodleukaemiainavaccinetrialinfinland
AT grovesf haemophilusinfluenzaetypebvaccinationandriskofchildhoodleukaemiainavaccinetrialinfinland

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