BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotype

INTRODUCTION: Individuals with germline mutations in the BRCA1 gene have an elevated risk of developing breast cancer, and often display characteristic clinicopathological features. We hypothesised that inactivation of BRCA1 by promoter methylation could occur as a germline or an early somatic event...

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Detalles Bibliográficos
Autores principales: Snell, Cameron, Krypuy, Michael, Wong, Ee Ming, Loughrey, Maurice B, Dobrovic, Alexander
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374968/
https://www.ncbi.nlm.nih.gov/pubmed/18269736
http://dx.doi.org/10.1186/bcr1858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374968/
https://www.ncbi.nlm.nih.gov/pubmed/18269736
http://dx.doi.org/10.1186/bcr1858

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