Cargando…
Breast cancer subtypes and survival in patients with brain metastases
INTRODUCTION: Brain metastases (BM) occur in up to one third of patients with metastatic breast cancer (MBC), whose incidences and prognoses by breast cancer subtypes in BM have not been well delineated. METHODS: Retrospective survival analyses were performed in 126 BM patients from 805 MBC patients...
Autores principales: | , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374976/ https://www.ncbi.nlm.nih.gov/pubmed/18307763 http://dx.doi.org/10.1186/bcr1870 |
_version_ | 1782154550255288320 |
---|---|
author | Nam, Byung-Ho Kim, Sun Young Han, Hye-Sook Kwon, Youngmee Lee, Keun Seok Kim, Tae Hyun Ro, Jungsil |
author_facet | Nam, Byung-Ho Kim, Sun Young Han, Hye-Sook Kwon, Youngmee Lee, Keun Seok Kim, Tae Hyun Ro, Jungsil |
author_sort | Nam, Byung-Ho |
collection | PubMed |
description | INTRODUCTION: Brain metastases (BM) occur in up to one third of patients with metastatic breast cancer (MBC), whose incidences and prognoses by breast cancer subtypes in BM have not been well delineated. METHODS: Retrospective survival analyses were performed in 126 BM patients from 805 MBC patients treated at the National Cancer Center between August 2001 and April 2006, according to clinical characteristics, breast cancer subtypes, and receipt of trastuzumab. Estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth receptor-2 (HER2) statuses were tested by immunohistochemical (IHC) staining, and HER2 FISH analysis conducted for IHC 2+. RESULTS: The proportion of HER2+/ER- (29% vs 16%) and triple-negative (37% vs 25%) tumors was higher in the 126 BM patients than those without BM. While median survival after recurrence was longer in patients with luminal A disease (median survival of luminal A vs luminal B vs HER2+/ER- vs triple-negative: p = 0.0246; 39.6 vs 27.4 vs 20.9 vs 15.5 months), survival was shorter from BM to death in luminal A and triple negatives (median survival: p = 0.0113; 4.0 vs 9.2 vs 5.0 vs 3.4 months). Receipt of trastuzumab after BM was a significant variable for survival in HER2+ patients. Multivariate analyses identified ER-negative, HER2-negative, or triple-negative, as well as older age, presence of leptomeningeal disease, and three or more extracranial disease sites, as poor prognostic factors for survival after BM. CONCLUSION: MBC patients who developed BM had higher proportions of triple-negative and HER2+/ER- tumor status. Triple receptor status is a useful prognostic marker for predicting survival after BM in metastatic breast cancer patients. |
format | Text |
id | pubmed-2374976 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-23749762008-05-10 Breast cancer subtypes and survival in patients with brain metastases Nam, Byung-Ho Kim, Sun Young Han, Hye-Sook Kwon, Youngmee Lee, Keun Seok Kim, Tae Hyun Ro, Jungsil Breast Cancer Res Research Article INTRODUCTION: Brain metastases (BM) occur in up to one third of patients with metastatic breast cancer (MBC), whose incidences and prognoses by breast cancer subtypes in BM have not been well delineated. METHODS: Retrospective survival analyses were performed in 126 BM patients from 805 MBC patients treated at the National Cancer Center between August 2001 and April 2006, according to clinical characteristics, breast cancer subtypes, and receipt of trastuzumab. Estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth receptor-2 (HER2) statuses were tested by immunohistochemical (IHC) staining, and HER2 FISH analysis conducted for IHC 2+. RESULTS: The proportion of HER2+/ER- (29% vs 16%) and triple-negative (37% vs 25%) tumors was higher in the 126 BM patients than those without BM. While median survival after recurrence was longer in patients with luminal A disease (median survival of luminal A vs luminal B vs HER2+/ER- vs triple-negative: p = 0.0246; 39.6 vs 27.4 vs 20.9 vs 15.5 months), survival was shorter from BM to death in luminal A and triple negatives (median survival: p = 0.0113; 4.0 vs 9.2 vs 5.0 vs 3.4 months). Receipt of trastuzumab after BM was a significant variable for survival in HER2+ patients. Multivariate analyses identified ER-negative, HER2-negative, or triple-negative, as well as older age, presence of leptomeningeal disease, and three or more extracranial disease sites, as poor prognostic factors for survival after BM. CONCLUSION: MBC patients who developed BM had higher proportions of triple-negative and HER2+/ER- tumor status. Triple receptor status is a useful prognostic marker for predicting survival after BM in metastatic breast cancer patients. BioMed Central 2008 2008-02-28 /pmc/articles/PMC2374976/ /pubmed/18307763 http://dx.doi.org/10.1186/bcr1870 Text en Copyright © 2008 Nam et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Nam, Byung-Ho Kim, Sun Young Han, Hye-Sook Kwon, Youngmee Lee, Keun Seok Kim, Tae Hyun Ro, Jungsil Breast cancer subtypes and survival in patients with brain metastases |
title | Breast cancer subtypes and survival in patients with brain metastases |
title_full | Breast cancer subtypes and survival in patients with brain metastases |
title_fullStr | Breast cancer subtypes and survival in patients with brain metastases |
title_full_unstemmed | Breast cancer subtypes and survival in patients with brain metastases |
title_short | Breast cancer subtypes and survival in patients with brain metastases |
title_sort | breast cancer subtypes and survival in patients with brain metastases |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374976/ https://www.ncbi.nlm.nih.gov/pubmed/18307763 http://dx.doi.org/10.1186/bcr1870 |
work_keys_str_mv | AT nambyungho breastcancersubtypesandsurvivalinpatientswithbrainmetastases AT kimsunyoung breastcancersubtypesandsurvivalinpatientswithbrainmetastases AT hanhyesook breastcancersubtypesandsurvivalinpatientswithbrainmetastases AT kwonyoungmee breastcancersubtypesandsurvivalinpatientswithbrainmetastases AT leekeunseok breastcancersubtypesandsurvivalinpatientswithbrainmetastases AT kimtaehyun breastcancersubtypesandsurvivalinpatientswithbrainmetastases AT rojungsil breastcancersubtypesandsurvivalinpatientswithbrainmetastases |