RASTA-Bacteria: a web-based tool for identifying toxin-antitoxin loci in prokaryotes

Toxin/antitoxin (TA) systems, viewed as essential regulators of growth arrest and programmed cell death, are widespread among prokaryotes, but remain sparsely annotated. We present RASTA-Bacteria, an automated method allowing quick and reliable identification of TA loci in sequenced prokaryotic geno...

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Detalles Bibliográficos
Autores principales: Sevin, Emeric W, Barloy-Hubler, Frédérique
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374986/
https://www.ncbi.nlm.nih.gov/pubmed/17678530
http://dx.doi.org/10.1186/gb-2007-8-8-r155
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author Sevin, Emeric W
Barloy-Hubler, Frédérique
author_facet Sevin, Emeric W
Barloy-Hubler, Frédérique
author_sort Sevin, Emeric W
collection PubMed
description Toxin/antitoxin (TA) systems, viewed as essential regulators of growth arrest and programmed cell death, are widespread among prokaryotes, but remain sparsely annotated. We present RASTA-Bacteria, an automated method allowing quick and reliable identification of TA loci in sequenced prokaryotic genomes, whether they are annotated open reading frames or not. The tool successfully confirmed all reported TA systems, and spotted new putative loci upon screening of sequenced genomes. RASTA-Bacteria is publicly available at .
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spelling pubmed-23749862008-05-12 RASTA-Bacteria: a web-based tool for identifying toxin-antitoxin loci in prokaryotes Sevin, Emeric W Barloy-Hubler, Frédérique Genome Biol Software Toxin/antitoxin (TA) systems, viewed as essential regulators of growth arrest and programmed cell death, are widespread among prokaryotes, but remain sparsely annotated. We present RASTA-Bacteria, an automated method allowing quick and reliable identification of TA loci in sequenced prokaryotic genomes, whether they are annotated open reading frames or not. The tool successfully confirmed all reported TA systems, and spotted new putative loci upon screening of sequenced genomes. RASTA-Bacteria is publicly available at . BioMed Central 2007 2007-08-01 /pmc/articles/PMC2374986/ /pubmed/17678530 http://dx.doi.org/10.1186/gb-2007-8-8-r155 Text en Copyright © 2007 Sevin and Barloy-Hubler; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Software
Sevin, Emeric W
Barloy-Hubler, Frédérique
RASTA-Bacteria: a web-based tool for identifying toxin-antitoxin loci in prokaryotes
title RASTA-Bacteria: a web-based tool for identifying toxin-antitoxin loci in prokaryotes
title_full RASTA-Bacteria: a web-based tool for identifying toxin-antitoxin loci in prokaryotes
title_fullStr RASTA-Bacteria: a web-based tool for identifying toxin-antitoxin loci in prokaryotes
title_full_unstemmed RASTA-Bacteria: a web-based tool for identifying toxin-antitoxin loci in prokaryotes
title_short RASTA-Bacteria: a web-based tool for identifying toxin-antitoxin loci in prokaryotes
title_sort rasta-bacteria: a web-based tool for identifying toxin-antitoxin loci in prokaryotes
topic Software
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374986/
https://www.ncbi.nlm.nih.gov/pubmed/17678530
http://dx.doi.org/10.1186/gb-2007-8-8-r155
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