Network motif analysis of a multi-mode genetic-interaction network

Different modes of genetic interaction indicate different functional relationships between genes. The extraction of biological information from dense multi-mode genetic-interaction networks demands appropriate statistical and computational methods. We developed such methods and implemented them in o...

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Detalles Bibliográficos
Autores principales: Taylor, R James, Siegel, Andrew F, Galitski, Timothy
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374991/
https://www.ncbi.nlm.nih.gov/pubmed/17683534
http://dx.doi.org/10.1186/gb-2007-8-8-r160
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author Taylor, R James
Siegel, Andrew F
Galitski, Timothy
author_facet Taylor, R James
Siegel, Andrew F
Galitski, Timothy
author_sort Taylor, R James
collection PubMed
description Different modes of genetic interaction indicate different functional relationships between genes. The extraction of biological information from dense multi-mode genetic-interaction networks demands appropriate statistical and computational methods. We developed such methods and implemented them in open-source software. Motifs extracted from multi-mode genetic-interaction networks form functional subnetworks, highlight genes dominating these subnetworks, and reveal genetic reflections of the underlying biochemical system.
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spelling pubmed-23749912008-05-10 Network motif analysis of a multi-mode genetic-interaction network Taylor, R James Siegel, Andrew F Galitski, Timothy Genome Biol Method Different modes of genetic interaction indicate different functional relationships between genes. The extraction of biological information from dense multi-mode genetic-interaction networks demands appropriate statistical and computational methods. We developed such methods and implemented them in open-source software. Motifs extracted from multi-mode genetic-interaction networks form functional subnetworks, highlight genes dominating these subnetworks, and reveal genetic reflections of the underlying biochemical system. BioMed Central 2007 2007-08-02 /pmc/articles/PMC2374991/ /pubmed/17683534 http://dx.doi.org/10.1186/gb-2007-8-8-r160 Text en Copyright © 2007 Taylor et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Method
Taylor, R James
Siegel, Andrew F
Galitski, Timothy
Network motif analysis of a multi-mode genetic-interaction network
title Network motif analysis of a multi-mode genetic-interaction network
title_full Network motif analysis of a multi-mode genetic-interaction network
title_fullStr Network motif analysis of a multi-mode genetic-interaction network
title_full_unstemmed Network motif analysis of a multi-mode genetic-interaction network
title_short Network motif analysis of a multi-mode genetic-interaction network
title_sort network motif analysis of a multi-mode genetic-interaction network
topic Method
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374991/
https://www.ncbi.nlm.nih.gov/pubmed/17683534
http://dx.doi.org/10.1186/gb-2007-8-8-r160
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