Cross-species cluster co-conservation: a new method for generating protein interaction networks

Co-conservation (phylogenetic profiles) is a well-established method for predicting functional relationships between proteins. Several publicly available databases use this method and additional clustering strategies to develop networks of protein interactions (cluster co-conservation (CCC)). CCC ha...

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Detalles Bibliográficos
Autores principales: Karimpour-Fard, Anis, Detweiler, Corrella S, Erickson, Kimberly D, Hunter, Lawrence, Gill, Ryan T
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375023/
https://www.ncbi.nlm.nih.gov/pubmed/17803817
http://dx.doi.org/10.1186/gb-2007-8-9-r185
Descripción
Sumario:Co-conservation (phylogenetic profiles) is a well-established method for predicting functional relationships between proteins. Several publicly available databases use this method and additional clustering strategies to develop networks of protein interactions (cluster co-conservation (CCC)). CCC has previously been limited to interactions within a single target species. We have extended CCC to develop protein interaction networks based on co-conservation between protein pairs across multiple species, cross-species cluster co-conservation.

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